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• W2051298762 startingPage "1809" @default.
• W2051298762 abstract "Suppressor T cells have been shown to be much more radiosensitive than other lymphoïd cells, and we have tried to reduce tumor growth by low-dose irradiation. Syngeneic DBA/2 mice received whole-body irradiation (150 rads; 1 rad = 0.01 J/kg) 6 days after P815 tumor inoculation. Tumor growth is significantly reduced in mildly irradiated mice. We also attempted to reduce syngeneic tumor growth by raising immunity against suppressor T cells in two different systems. DBA/2 mice were immunized against splenic T cells collected after disappearance of cytotoxicity and then injected with P815 tumor cells. These mice develop a very high primary cytotoxicity against P815 cells. C57BL/6 mice were immunized against blastic suppressor T cells, before injection of T2 tumor cells. Some of these mice reject the tumor and other develop smaller tumors than control mice. These results could be explained by the induction of antiidiotypic activity directed against the immunological receptors of suppressor T lymphocytes, because immunization with blastic suppressor T cells from mice bearing the T2 tumor does not modify the growth of another tumor, T10." @default.
• W2051298762 created "2016-06-24" @default.
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• W2051298762 date "1981-03-01" @default.
• W2051298762 modified "2023-09-25" @default.
• W2051298762 title "Reduced tumor growth after low-dose irradiation or immunization against blastic suppressor T cells." @default.
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• W2051298762 doi "https://doi.org/10.1073/pnas.78.3.1809" @default.
• W2051298762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/319224" @default.
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