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• W2051299325 abstract "Natural killer (NK) cells are the main lymphoid population in the maternal decidua during the first trimester of pregnancy. Decidual NK (dNK) cells display a unique functional profile and play a key role in promoting tissue remodeling, neoangiogenesis, and immune modulation. However, little information exists on their origin and development. Here we discovered CD34 + hematopoietic precursors in human decidua (dCD34 + ). We show that dCD34 + cells differ from cord blood- or peripheral blood-derived CD34 + precursors. The expression of IL-15/IL-2 receptor common β-chain (CD122), IL-7 receptor α-chain (CD127), and mRNA for E4BP4 and ID2 transcription factors suggested that dCD34 + cells are committed to the NK cell lineage. Moreover, they could undergo in vitro differentiation into functional (i.e., IL-8– and IL-22–producing) CD56 bright CD16 − KIR +/− NK cells in the presence of growth factors or even upon coculture with decidual stromal cells. Their NK cell commitment was further supported by the failure to undergo myeloid differentiation in the presence of GM-CSF. Our findings strongly suggest that decidual NK cells may directly derive from CD34 + cell precursors present in the decidua upon specific cellular interactions with components of the decidual microenvironment." @default.
• W2051299325 created "2016-06-24" @default.
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• W2051299325 date "2011-01-19" @default.
• W2051299325 modified "2023-10-09" @default.
• W2051299325 title "CD34 ⁺ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells" @default.
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• W2051299325 doi "https://doi.org/10.1073/pnas.1016257108" @default.
• W2051299325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3038730" @default.
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