Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051299739> ?p ?o ?g. }
- W2051299739 endingPage "951" @default.
- W2051299739 startingPage "944" @default.
- W2051299739 abstract "PICT1 (also known as GLTSCR2) is considered a tumor suppressor because it stabilizes phosphatase and tensin homolog (PTEN), but individuals with oligodendrogliomas lacking chromosome 19q13, where PICT1 is located, have better prognoses than other oligodendroglioma patients. To clarify the function of PICT1, we generated Pict1-deficient mice and embryonic stem (ES) cells. Pict1 is a nucleolar protein essential for embryogenesis and ES cell survival. Even without DNA damage, Pict1 loss led to p53-dependent arrest of cell cycle phase G(1) and apoptosis. Pict1-deficient cells accumulated p53, owing to impaired Mdm2 function. Pict1 binds Rpl11, and Rpl11 is released from nucleoli in the absence of Pict1. In Pict1-deficient cells, increased binding of Rpl11 to Mdm2 blocks Mdm2-mediated ubiquitination of p53. In human cancer, individuals whose tumors express less PICT1 have better prognoses. When PICT1 is depleted in tumor cells with intact P53 signaling, the cells grow more slowly and accumulate P53. Thus, PICT1 is a potent regulator of the MDM2-P53 pathway and promotes tumor progression by retaining RPL11 in the nucleolus." @default.
- W2051299739 created "2016-06-24" @default.
- W2051299739 creator A5000800493 @default.
- W2051299739 creator A5002530970 @default.
- W2051299739 creator A5005802003 @default.
- W2051299739 creator A5006300612 @default.
- W2051299739 creator A5016865613 @default.
- W2051299739 creator A5017606167 @default.
- W2051299739 creator A5018967580 @default.
- W2051299739 creator A5022009756 @default.
- W2051299739 creator A5023970944 @default.
- W2051299739 creator A5028798909 @default.
- W2051299739 creator A5040718533 @default.
- W2051299739 creator A5042290434 @default.
- W2051299739 creator A5044707863 @default.
- W2051299739 creator A5053811370 @default.
- W2051299739 creator A5054352845 @default.
- W2051299739 creator A5064427269 @default.
- W2051299739 creator A5067647817 @default.
- W2051299739 creator A5070373092 @default.
- W2051299739 creator A5074588035 @default.
- W2051299739 creator A5076340516 @default.
- W2051299739 creator A5078085024 @default.
- W2051299739 creator A5078287634 @default.
- W2051299739 creator A5080267048 @default.
- W2051299739 date "2011-07-31" @default.
- W2051299739 modified "2023-10-02" @default.
- W2051299739 title "Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11" @default.
- W2051299739 cites W1591281137 @default.
- W2051299739 cites W1963795701 @default.
- W2051299739 cites W1965090530 @default.
- W2051299739 cites W1965967919 @default.
- W2051299739 cites W1968220278 @default.
- W2051299739 cites W1968466970 @default.
- W2051299739 cites W1969340179 @default.
- W2051299739 cites W1969437200 @default.
- W2051299739 cites W1970845818 @default.
- W2051299739 cites W1972166647 @default.
- W2051299739 cites W1975786537 @default.
- W2051299739 cites W1977434038 @default.
- W2051299739 cites W1983751803 @default.
- W2051299739 cites W1992307025 @default.
- W2051299739 cites W1999440327 @default.
- W2051299739 cites W1999712823 @default.
- W2051299739 cites W2001493754 @default.
- W2051299739 cites W2004446968 @default.
- W2051299739 cites W2009514561 @default.
- W2051299739 cites W2013606253 @default.
- W2051299739 cites W2019361551 @default.
- W2051299739 cites W2020124633 @default.
- W2051299739 cites W2025147250 @default.
- W2051299739 cites W2025476423 @default.
- W2051299739 cites W2025722611 @default.
- W2051299739 cites W2028923735 @default.
- W2051299739 cites W2034223072 @default.
- W2051299739 cites W2039463309 @default.
- W2051299739 cites W2045914521 @default.
- W2051299739 cites W2046505220 @default.
- W2051299739 cites W2049667730 @default.
- W2051299739 cites W2053586237 @default.
- W2051299739 cites W2056530510 @default.
- W2051299739 cites W2057087535 @default.
- W2051299739 cites W2059995145 @default.
- W2051299739 cites W2062919433 @default.
- W2051299739 cites W2082979850 @default.
- W2051299739 cites W2083309296 @default.
- W2051299739 cites W2088412411 @default.
- W2051299739 cites W2107120959 @default.
- W2051299739 cites W2112706571 @default.
- W2051299739 cites W2120489590 @default.
- W2051299739 cites W2120775866 @default.
- W2051299739 cites W2121331514 @default.
- W2051299739 cites W2131250046 @default.
- W2051299739 cites W2140899494 @default.
- W2051299739 cites W2141431050 @default.
- W2051299739 cites W2141529421 @default.
- W2051299739 cites W2142994892 @default.
- W2051299739 cites W2157088766 @default.
- W2051299739 cites W2158456335 @default.
- W2051299739 doi "https://doi.org/10.1038/nm.2392" @default.
- W2051299739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4578312" @default.
- W2051299739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21804542" @default.
- W2051299739 hasPublicationYear "2011" @default.
- W2051299739 type Work @default.
- W2051299739 sameAs 2051299739 @default.
- W2051299739 citedByCount "164" @default.
- W2051299739 countsByYear W20512997392012 @default.
- W2051299739 countsByYear W20512997392013 @default.
- W2051299739 countsByYear W20512997392014 @default.
- W2051299739 countsByYear W20512997392015 @default.
- W2051299739 countsByYear W20512997392016 @default.
- W2051299739 countsByYear W20512997392017 @default.
- W2051299739 countsByYear W20512997392018 @default.
- W2051299739 countsByYear W20512997392019 @default.
- W2051299739 countsByYear W20512997392020 @default.
- W2051299739 countsByYear W20512997392021 @default.
- W2051299739 countsByYear W20512997392022 @default.
- W2051299739 countsByYear W20512997392023 @default.