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- W2051299852 abstract "Quite often patients affected by chronic HCV infection show no clinical signs of liver disease and display persistently normal aminotransferase values. These patients, defined “healthy or asymptomatic carriers,” can have active viral replication and various degrees of histological liver damage. Aim: To verify, in a population of healthy anti-HCV-positive carriers, if the aminotransferases of viremics (although in the normal range) are considerably different from those of non viremics. Patients and Methods: We followed 26 healthy anti-HCV-positive subjects (17 HCV-RNA+ and 9 HCV-RNA-) by determining ALT and AST at 3-month intervals for an average of 2.6 years (range l-4). Results: During the entire follow-up, aminotransferases persistently remained in the normal range on all samples (237 testings: 150 HCV-RNA+ and 87 HCV-RNA-). The ALT mean was 0.618 t0.171 x maximum normal value (MNV) and 0.434 k 0.153 x MNV respectively in the HCV-RNA+ and in the HCVRNAsubjects (p< 0.001). The same consistent difference in AST mean values of the two groups was also evidenced (0.652 + 0.168 and 0.528 + 0.150 x MNV; p< 0.001). Conclusions: In healthy HCV carriers, infection generally progresses with modest cytolytic activity and therefore, the current MNV are misleading." @default.
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- W2051299852 date "1998-01-01" @default.
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- W2051299852 title "Different distribution of aminotrans-ferase values among healthy HCV carriers in relation to presence/absence of viremia" @default.
- W2051299852 doi "https://doi.org/10.1016/s0168-8278(98)80956-2" @default.
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