FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051299998> ?p ?o ?g. }

• W2051299998 endingPage "e16967" @default.
• W2051299998 startingPage "e16967" @default.
• W2051299998 abstract "Background There have been conflicting reports of the role of Type I interferons (IFN) in inflammatory bowel disease (IBD). Clinical trials have shown potent efficacy of systemic interferon-beta (IFN-β) in inducing remission of ulcerative colitis. Likewise, IFNAR1−/− mice display an increased sensitivity to dextran sulfate sodium (DSS)-induced colitis, suggesting Type I IFN play a protective role during inflammation of the gut. Curiously, however, there have also been reports detailing the spontaneous development of IBD in patients receiving systemic IFN-β therapy for multiple sclerosis or hepatitis. Methodology/Principal Findings To investigate the effects of local administration of IFN-β on a murine model of colitis, we developed a transgenic Lactobacillus acidophilus strain that constitutively expresses IFN-β (La-IFN-β). While pretreatment of mice with control Lactobacillus (La-EV) provided slight protective benefits, La-IFN-β increased sensitivity to DSS. Analysis showed colitic mice pretreated with La-IFN-β had increased production of TNF-α, IFN-γ, IL-17A and IL-13 by intestinal tissues and decreased regulatory T cells (Tregs) in their small intestine. Examination of CD103+ dendritic cells (DCs) in the Peyer's patches revealed that IFNAR1 expression was dramatically reduced by La-IFN-β. Similarly, bone marrow-derived DCs matured with La-IFN-β experienced a 3-fold reduction of IFNAR1 and were impaired in their ability to induce Tregs. Conclusions/Significance Our IFNAR1 expression data identifies a correlation between the loss/downregulation of IFNAR1 on DCs and exacerbation of colitis. Our data show that Lactobacillus secreting IFN-β has an immunological effect that in our model results in the exacerbation of colitis. This study underscores that the selection of therapeutics delivered by a bacterial vehicle must take into consideration the simultaneous effects of the vehicle itself." @default.
• W2051299998 created "2016-06-24" @default.
• W2051299998 creator A5009832327 @default.
• W2051299998 creator A5032251844 @default.
• W2051299998 creator A5033518970 @default.
• W2051299998 creator A5034713583 @default.
• W2051299998 creator A5035167338 @default.
• W2051299998 creator A5052269454 @default.
• W2051299998 creator A5077087163 @default.
• W2051299998 creator A5090914300 @default.
• W2051299998 date "2011-02-18" @default.
• W2051299998 modified "2023-09-23" @default.
• W2051299998 title "Localized Delivery of Interferon-β by Lactobacillus Exacerbates Experimental Colitis" @default.
• W2051299998 cites W1509473864 @default.
• W2051299998 cites W1542489867 @default.
• W2051299998 cites W1599671085 @default.
• W2051299998 cites W1921059762 @default.
• W2051299998 cites W1968062583 @default.
• W2051299998 cites W1968168664 @default.
• W2051299998 cites W1971782933 @default.
• W2051299998 cites W1979324447 @default.
• W2051299998 cites W1981380968 @default.
• W2051299998 cites W1991872145 @default.
• W2051299998 cites W1992344864 @default.
• W2051299998 cites W1997384271 @default.
• W2051299998 cites W1999283406 @default.
• W2051299998 cites W2010057339 @default.
• W2051299998 cites W2014743999 @default.
• W2051299998 cites W2016297238 @default.
• W2051299998 cites W2017888326 @default.
• W2051299998 cites W2018954400 @default.
• W2051299998 cites W2019926860 @default.
• W2051299998 cites W2022075225 @default.
• W2051299998 cites W2023850749 @default.
• W2051299998 cites W2024061399 @default.
• W2051299998 cites W2024263435 @default.
• W2051299998 cites W2025431064 @default.
• W2051299998 cites W2027449693 @default.
• W2051299998 cites W2028402416 @default.
• W2051299998 cites W2035213168 @default.
• W2051299998 cites W2039388494 @default.
• W2051299998 cites W2041160872 @default.
• W2051299998 cites W2043683764 @default.
• W2051299998 cites W2045848719 @default.
• W2051299998 cites W2046160290 @default.
• W2051299998 cites W2050052221 @default.
• W2051299998 cites W2051529467 @default.
• W2051299998 cites W2065307318 @default.
• W2051299998 cites W2077161102 @default.
• W2051299998 cites W2077417036 @default.
• W2051299998 cites W2078844752 @default.
• W2051299998 cites W2079425775 @default.
• W2051299998 cites W2083323027 @default.
• W2051299998 cites W2091587044 @default.
• W2051299998 cites W2097262511 @default.
• W2051299998 cites W2101567516 @default.
• W2051299998 cites W2103465511 @default.
• W2051299998 cites W2105221079 @default.
• W2051299998 cites W2107369528 @default.
• W2051299998 cites W2107952237 @default.
• W2051299998 cites W2113526866 @default.
• W2051299998 cites W2114424280 @default.
• W2051299998 cites W2122082443 @default.
• W2051299998 cites W2123257865 @default.
• W2051299998 cites W2125196174 @default.
• W2051299998 cites W2126874760 @default.
• W2051299998 cites W2142838774 @default.
• W2051299998 cites W2144013613 @default.
• W2051299998 cites W2151109138 @default.
• W2051299998 cites W2155399403 @default.
• W2051299998 cites W2156313733 @default.
• W2051299998 cites W2159043580 @default.
• W2051299998 cites W2166676682 @default.
• W2051299998 cites W2316029989 @default.
• W2051299998 cites W4253323169 @default.
• W2051299998 doi "https://doi.org/10.1371/journal.pone.0016967" @default.
• W2051299998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3041828" @default.
• W2051299998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21365015" @default.
• W2051299998 hasPublicationYear "2011" @default.
• W2051299998 type Work @default.
• W2051299998 sameAs 2051299998 @default.
• W2051299998 citedByCount "26" @default.
• W2051299998 countsByYear W20512999982012 @default.
• W2051299998 countsByYear W20512999982013 @default.
• W2051299998 countsByYear W20512999982014 @default.
• W2051299998 countsByYear W20512999982015 @default.
• W2051299998 countsByYear W20512999982016 @default.
• W2051299998 countsByYear W20512999982017 @default.
• W2051299998 countsByYear W20512999982018 @default.
• W2051299998 countsByYear W20512999982019 @default.
• W2051299998 countsByYear W20512999982021 @default.
• W2051299998 countsByYear W20512999982022 @default.
• W2051299998 countsByYear W20512999982023 @default.
• W2051299998 crossrefType "journal-article" @default.
• W2051299998 hasAuthorship W2051299998A5009832327 @default.
• W2051299998 hasAuthorship W2051299998A5032251844 @default.
• W2051299998 hasAuthorship W2051299998A5033518970 @default.
• W2051299998 hasAuthorship W2051299998A5034713583 @default.

• next