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• W2051311394 abstract "Evidence indicates that high density lipoprotein (HDL) is cardioprotective and that several mechanisms are involved. One important pathway is a membrane-associated ATP-binding cassette transporter, ABCA1, that clears cholesterol from macrophage foam cells. Anti-inflammatory and antioxidant properties also might contribute to HDL's ability to inhibit atherosclerosis.Myeloperoxidase targets HDL for oxidation, raising the possibility that the enzyme provides a specific mechanism for generating dysfunctional HDL in humans. Myeloperoxidase-dependent oxidation of apolipoprotein A-I, the major protein in HDL, blocks HDL's ability to remove excess cholesterol from cells by the ABCA1 pathway. Analysis of mutated forms of apoA-I and oxidized apoA-I treated with methionine sulfoxide reductase implicate oxidation of specific tyrosine and methionine residues in impairing the ABCA1 transport activity of apoA-I. The crystal structure of lipid-free apoA-I suggests that such oxidative damage might disrupt negatively charged regions on the protein's surface or alter its remodeling, resulting in conformations that fail to interact with ABCA1.Oxidation of HDL by myeloperoxidase may represent a specific molecular mechanism for converting the cardioprotective lipoprotein into a dysfunctional form, raising the possibility that the enzyme represents a potential therapeutic target for preventing vascular disease in humans. Moreover, oxidized HDL might prove useful as a blood marker for clinically significant cardiovascular disease in humans." @default.
• W2051311394 created "2016-06-24" @default.
• W2051311394 creator A5026547402 @default.
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• W2051311394 date "2006-07-01" @default.
• W2051311394 modified "2023-10-16" @default.
• W2051311394 title "Myeloperoxidase: an inflammatory enzyme for generating dysfunctional high density lipoprotein" @default.
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• W2051311394 doi "https://doi.org/10.1097/01.hco.0000231402.87232.aa" @default.
• W2051311394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16755201" @default.
• W2051311394 hasPublicationYear "2006" @default.
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