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- W2051319139 abstract "The acid mucopolysaccharide content, composition and molecular weight distribution in cortex, medulla and papilla of kidneys from normal subjects and from one patient each with mucopolysaccharidosis type I (Hurler) and type II (Hunter) were determined. It was found that heparitin sulfate and hyaluronic acid were the major acid mucopolysaccharides in normal human kidneys, the former predominating in the cortex and the latter in the medulla and papilla. The total amount of acid mucopolysaccharides in the kidneys from the patients with mucopolysaccharidoses was more than ten times higher than in the unaffected controls. In addition, there was an increase of 15- to 50-fold in the dermatan sulfate, and of 3- to 5-fold in the heparin sulfate content and a drastic shift in the molecular weight distribution towards smaller molecules." @default.
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- W2051319139 date "1973-06-01" @default.
- W2051319139 modified "2023-10-18" @default.
- W2051319139 title "Acid mucopolysaccharides (glycosaminoglycans) in normal human kidneys and in kidneys of patients with mucopolysaccharidoses" @default.
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- W2051319139 doi "https://doi.org/10.1016/0006-2944(73)90058-6" @default.
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