FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051321639> ?p ?o ?g. }

• W2051321639 endingPage "988" @default.
• W2051321639 startingPage "982" @default.
• W2051321639 abstract "The mutagenicity and genotoxicity of cis-[Pt(NH3)2[d(GpG)-N7(1),-N7(2)]] (G*G*), the major DNA adduct of the antitumor drug cisplatin, has been investigated in Escherichia coli. A duplex bacteriophage M13 genome was constructed to contain the G*G* adduct at a specific site in the (-) strand. The singly platinated duplex genome exhibited a survival of 22% relative to that of the unplatinated control genomes, and this value rose to 38% in cells treated with ultraviolet light to induce the SOS response. Singly platinated single-stranded genomes were also produced. Replication of the single- and double-stranded genomes in vivo yielded SOS-dependent, targeted mutations at frequencies of 1.3% and 0.16%, respectively. The mutagenic specificity of G*G* in both single- and double-stranded DNA was striking in that 80-90% of the mutations occurred at the 5'-platinated G. Approximately 80% of the mutations were G-->T transversions at that site. A model of mutagenesis is presented to explain this mutational specificity with respect to current understanding of platinum-DNA adduct structure." @default.
• W2051321639 created "2016-06-24" @default.
• W2051321639 creator A5009785229 @default.
• W2051321639 creator A5034625027 @default.
• W2051321639 creator A5059624337 @default.
• W2051321639 creator A5067156333 @default.
• W2051321639 date "1993-01-26" @default.
• W2051321639 modified "2023-10-09" @default.
• W2051321639 title "Mutagenicity and genotoxicity of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum(II)" @default.
• W2051321639 cites W1551844480 @default.
• W2051321639 cites W1601687245 @default.
• W2051321639 cites W1645529802 @default.
• W2051321639 cites W1965547980 @default.
• W2051321639 cites W1970558504 @default.
• W2051321639 cites W1973331584 @default.
• W2051321639 cites W1975165425 @default.
• W2051321639 cites W1976453250 @default.
• W2051321639 cites W1977112287 @default.
• W2051321639 cites W1983271068 @default.
• W2051321639 cites W1983762073 @default.
• W2051321639 cites W1984367999 @default.
• W2051321639 cites W1984928446 @default.
• W2051321639 cites W1987415657 @default.
• W2051321639 cites W1987586745 @default.
• W2051321639 cites W1987940280 @default.
• W2051321639 cites W1988094074 @default.
• W2051321639 cites W1988348275 @default.
• W2051321639 cites W1989405000 @default.
• W2051321639 cites W1990889686 @default.
• W2051321639 cites W1993091822 @default.
• W2051321639 cites W1996803803 @default.
• W2051321639 cites W1997049208 @default.
• W2051321639 cites W2009215863 @default.
• W2051321639 cites W2016430241 @default.
• W2051321639 cites W2021183094 @default.
• W2051321639 cites W2026195203 @default.
• W2051321639 cites W2028130329 @default.
• W2051321639 cites W2032833465 @default.
• W2051321639 cites W2033817907 @default.
• W2051321639 cites W2033860973 @default.
• W2051321639 cites W2036166614 @default.
• W2051321639 cites W2036357898 @default.
• W2051321639 cites W2043285825 @default.
• W2051321639 cites W2045388444 @default.
• W2051321639 cites W2057954230 @default.
• W2051321639 cites W2062130291 @default.
• W2051321639 cites W2063134544 @default.
• W2051321639 cites W2064286820 @default.
• W2051321639 cites W2070394784 @default.
• W2051321639 cites W2074558212 @default.
• W2051321639 cites W2078049644 @default.
• W2051321639 cites W2082545983 @default.
• W2051321639 cites W2085031348 @default.
• W2051321639 cites W2094767801 @default.
• W2051321639 cites W2104646138 @default.
• W2051321639 cites W2114989573 @default.
• W2051321639 cites W2138270253 @default.
• W2051321639 cites W2159509082 @default.
• W2051321639 cites W2165559376 @default.
• W2051321639 cites W2228133195 @default.
• W2051321639 cites W2950849739 @default.
• W2051321639 cites W3005404090 @default.
• W2051321639 cites W67746198 @default.
• W2051321639 doi "https://doi.org/10.1021/bi00054a031" @default.
• W2051321639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8422401" @default.
• W2051321639 hasPublicationYear "1993" @default.
• W2051321639 type Work @default.
• W2051321639 sameAs 2051321639 @default.
• W2051321639 citedByCount "96" @default.
• W2051321639 countsByYear W20513216392012 @default.
• W2051321639 countsByYear W20513216392014 @default.
• W2051321639 countsByYear W20513216392015 @default.
• W2051321639 countsByYear W20513216392018 @default.
• W2051321639 countsByYear W20513216392020 @default.
• W2051321639 countsByYear W20513216392021 @default.
• W2051321639 crossrefType "journal-article" @default.
• W2051321639 hasAuthorship W2051321639A5009785229 @default.
• W2051321639 hasAuthorship W2051321639A5034625027 @default.
• W2051321639 hasAuthorship W2051321639A5059624337 @default.
• W2051321639 hasAuthorship W2051321639A5067156333 @default.
• W2051321639 hasBestOaLocation W20513216391 @default.
• W2051321639 hasConcept C104317684 @default.
• W2051321639 hasConcept C108204754 @default.
• W2051321639 hasConcept C141231307 @default.
• W2051321639 hasConcept C143425029 @default.
• W2051321639 hasConcept C153911025 @default.
• W2051321639 hasConcept C16318435 @default.
• W2051321639 hasConcept C178790620 @default.
• W2051321639 hasConcept C185592680 @default.
• W2051321639 hasConcept C2776694085 @default.
• W2051321639 hasConcept C2778239845 @default.
• W2051321639 hasConcept C2778959862 @default.
• W2051321639 hasConcept C2780852648 @default.
• W2051321639 hasConcept C2781247443 @default.
• W2051321639 hasConcept C29730261 @default.
• W2051321639 hasConcept C501734568 @default.
• W2051321639 hasConcept C54355233 @default.
• W2051321639 hasConcept C547475151 @default.

• next