FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051330571> ?p ?o ?g. }

• W2051330571 endingPage "732" @default.
• W2051330571 startingPage "725" @default.
• W2051330571 abstract "To investigate whether myosin light chain kinase (MLCK) contributed to the high proliferative ability of breast cancer cells. Soft agar colony formation on the MCF-7 and LM-MCF-7 cell lines was determined. The cell cycles of MCF-7 and LM-MCF-7 were detected using flow cytometry analysis. Western blot analysis was performed to detect the expression levels of p-ERK1/2, total-ERK1/2, p-p38, total p38, p-JNK, total-JNK, survivin, Bcl-2, p-MLC, caspase-9, cleaved caspase-9, and MLCK. After treatment with adriamycin (ADR), ML-7 and SB203580, apoptosis was examined using flow cytometry analysis and Annexin V-FITC fluorescence microscopy. The breast cancer LM-MCF-7 cell line with high metastasis potential (a metastitic sub-clone of MCF-7) had higher anti-apoptosis ability relative to MCF-7 cells in response to adriamycin treatment (apoptosis rate: 6.76% vs 28.58%, P<0.05). Moreover, the expression level of MLCK was upregulated and the level of phosphorylated p38 (p-p38) was decreased in LM-MCF-7 cells. Flow cytometry analysis showed that ML-7, selective inhibitor of MLCK, could induce apoptosis of the LM-MCF-7 cells, in which the level of p-p38 was increased. Meanwhile, the expression levels of Bcl-2 and survivin were downregulated, while the caspase-9 was upregulated suggesting that the cells were undergone apoptosis. Flow cytometry analysis showed that SB203580, an inhibitor of p38, abolished ML-7-induced apoptosis, which resulted in the upregualtion of Bcl-2 and survivin, and downregulation of caspase-9, suggesting that Bcl-2, survivin and caspase-9 are downstream effectors of p38. MLCK is responsible for high proliferative ability of breast cancer cells through anti-apoptosis, in which p38 pathway was involved." @default.
• W2051330571 created "2016-06-24" @default.
• W2051330571 creator A5008659449 @default.
• W2051330571 creator A5035804461 @default.
• W2051330571 creator A5039861450 @default.
• W2051330571 creator A5043838342 @default.
• W2051330571 creator A5045064102 @default.
• W2051330571 creator A5067645832 @default.
• W2051330571 date "2010-05-10" @default.
• W2051330571 modified "2023-10-18" @default.
• W2051330571 title "Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway" @default.
• W2051330571 cites W1533199841 @default.
• W2051330571 cites W1632452298 @default.
• W2051330571 cites W1964708202 @default.
• W2051330571 cites W1971996726 @default.
• W2051330571 cites W1980926721 @default.
• W2051330571 cites W1987560705 @default.
• W2051330571 cites W1989249434 @default.
• W2051330571 cites W1992361007 @default.
• W2051330571 cites W2025010861 @default.
• W2051330571 cites W2027428229 @default.
• W2051330571 cites W2049048127 @default.
• W2051330571 cites W2068156075 @default.
• W2051330571 cites W2070335110 @default.
• W2051330571 cites W2072319964 @default.
• W2051330571 cites W2073343697 @default.
• W2051330571 cites W2078172545 @default.
• W2051330571 cites W2080457188 @default.
• W2051330571 cites W2093549611 @default.
• W2051330571 cites W2095554214 @default.
• W2051330571 cites W2105266148 @default.
• W2051330571 cites W2118621558 @default.
• W2051330571 cites W2125751525 @default.
• W2051330571 cites W2140677435 @default.
• W2051330571 cites W2144777717 @default.
• W2051330571 cites W2145661576 @default.
• W2051330571 cites W2160062367 @default.
• W2051330571 cites W2168340241 @default.
• W2051330571 cites W2169305606 @default.
• W2051330571 doi "https://doi.org/10.1038/aps.2010.56" @default.
• W2051330571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4002978" @default.
• W2051330571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20453870" @default.
• W2051330571 hasPublicationYear "2010" @default.
• W2051330571 type Work @default.
• W2051330571 sameAs 2051330571 @default.
• W2051330571 citedByCount "39" @default.
• W2051330571 countsByYear W20513305712012 @default.
• W2051330571 countsByYear W20513305712013 @default.
• W2051330571 countsByYear W20513305712014 @default.
• W2051330571 countsByYear W20513305712015 @default.
• W2051330571 countsByYear W20513305712016 @default.
• W2051330571 countsByYear W20513305712017 @default.
• W2051330571 countsByYear W20513305712018 @default.
• W2051330571 countsByYear W20513305712019 @default.
• W2051330571 countsByYear W20513305712020 @default.
• W2051330571 countsByYear W20513305712021 @default.
• W2051330571 countsByYear W20513305712022 @default.
• W2051330571 countsByYear W20513305712023 @default.
• W2051330571 crossrefType "journal-article" @default.
• W2051330571 hasAuthorship W2051330571A5008659449 @default.
• W2051330571 hasAuthorship W2051330571A5035804461 @default.
• W2051330571 hasAuthorship W2051330571A5039861450 @default.
• W2051330571 hasAuthorship W2051330571A5043838342 @default.
• W2051330571 hasAuthorship W2051330571A5045064102 @default.
• W2051330571 hasAuthorship W2051330571A5067645832 @default.
• W2051330571 hasBestOaLocation W20513305711 @default.
• W2051330571 hasConcept C104317684 @default.
• W2051330571 hasConcept C109541995 @default.
• W2051330571 hasConcept C121608353 @default.
• W2051330571 hasConcept C127561419 @default.
• W2051330571 hasConcept C153911025 @default.
• W2051330571 hasConcept C184235292 @default.
• W2051330571 hasConcept C185592680 @default.
• W2051330571 hasConcept C190283241 @default.
• W2051330571 hasConcept C2775975398 @default.
• W2051330571 hasConcept C2994423619 @default.
• W2051330571 hasConcept C502942594 @default.
• W2051330571 hasConcept C51551487 @default.
• W2051330571 hasConcept C54355233 @default.
• W2051330571 hasConcept C553184892 @default.
• W2051330571 hasConcept C55493867 @default.
• W2051330571 hasConcept C6997183 @default.
• W2051330571 hasConcept C8035138 @default.
• W2051330571 hasConcept C86803240 @default.
• W2051330571 hasConcept C88634738 @default.
• W2051330571 hasConcept C95444343 @default.
• W2051330571 hasConcept C96232424 @default.
• W2051330571 hasConcept C97029542 @default.
• W2051330571 hasConceptScore W2051330571C104317684 @default.
• W2051330571 hasConceptScore W2051330571C109541995 @default.
• W2051330571 hasConceptScore W2051330571C121608353 @default.
• W2051330571 hasConceptScore W2051330571C127561419 @default.
• W2051330571 hasConceptScore W2051330571C153911025 @default.
• W2051330571 hasConceptScore W2051330571C184235292 @default.
• W2051330571 hasConceptScore W2051330571C185592680 @default.
• W2051330571 hasConceptScore W2051330571C190283241 @default.
• W2051330571 hasConceptScore W2051330571C2775975398 @default.
• W2051330571 hasConceptScore W2051330571C2994423619 @default.

• next