FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051330762> ?p ?o ?g. }

• W2051330762 endingPage "515" @default.
• W2051330762 startingPage "507" @default.
• W2051330762 abstract "Effects of hirsutine, an alkaloid that produces a potent ganglion blocking effect, were investigated using rat pheochromocytoma PC12 cells. Hirsutine (1 to 10 microM) suppressed dopamine-release evoked by 100 microM nicotine. In voltage-clamped cells, hirsutine (1 to 10 microM) inhibited the inward current activated by 100 microM nicotine. Hirsutine was equipotent to hexamethonium in blocking the nicotine-activated current. The voltage-dependency of the nicotine activated current was not modified by hirsutine. Effects of hirustine on other ion channels were tested to determine its selectivity. Inward currents mediated through ATP-activated channels were scarcely affected by hirsutine (up to 100 microM). However, hirustine (10 microM) inhibited Ba currents passing through Ca channels and K currents activated by depolarizing voltage steps. The results suggest that hirsutine potently blocks nicotinic receptor-channels, but hirsutine also inhibits voltage-gated Ca and K channels. Roles of the inhibition of these channels in the pharmacological effects of hirsutine were discussed." @default.
• W2051330762 created "2016-06-24" @default.
• W2051330762 creator A5001781318 @default.
• W2051330762 creator A5005347003 @default.
• W2051330762 creator A5006043634 @default.
• W2051330762 creator A5023916678 @default.
• W2051330762 creator A5036849676 @default.
• W2051330762 creator A5040860122 @default.
• W2051330762 creator A5059044821 @default.
• W2051330762 creator A5085634864 @default.
• W2051330762 date "1991-01-01" @default.
• W2051330762 modified "2023-09-23" @default.
• W2051330762 title "Inhibition of Ion Channels by Hirsutine in Rat Pheochromocytoma Cells." @default.
• W2051330762 cites W1639466988 @default.
• W2051330762 cites W1873621928 @default.
• W2051330762 cites W1967092185 @default.
• W2051330762 cites W1970587959 @default.
• W2051330762 cites W1986995324 @default.
• W2051330762 cites W1992407636 @default.
• W2051330762 cites W1993718844 @default.
• W2051330762 cites W2008640420 @default.
• W2051330762 cites W2009667219 @default.
• W2051330762 cites W2015124516 @default.
• W2051330762 cites W2019996404 @default.
• W2051330762 cites W2027763296 @default.
• W2051330762 cites W2042971475 @default.
• W2051330762 cites W2059639566 @default.
• W2051330762 cites W2070528456 @default.
• W2051330762 cites W2077142067 @default.
• W2051330762 cites W2284590122 @default.
• W2051330762 cites W2323884657 @default.
• W2051330762 cites W2324387369 @default.
• W2051330762 cites W2330643180 @default.
• W2051330762 cites W2333741918 @default.
• W2051330762 cites W2398717197 @default.
• W2051330762 cites W2460169201 @default.
• W2051330762 cites W3106340468 @default.
• W2051330762 doi "https://doi.org/10.1254/jjp.57.507" @default.
• W2051330762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1724991" @default.
• W2051330762 hasPublicationYear "1991" @default.
• W2051330762 type Work @default.
• W2051330762 sameAs 2051330762 @default.
• W2051330762 citedByCount "11" @default.
• W2051330762 countsByYear W20513307622012 @default.
• W2051330762 countsByYear W20513307622018 @default.
• W2051330762 crossrefType "journal-article" @default.
• W2051330762 hasAuthorship W2051330762A5001781318 @default.
• W2051330762 hasAuthorship W2051330762A5005347003 @default.
• W2051330762 hasAuthorship W2051330762A5006043634 @default.
• W2051330762 hasAuthorship W2051330762A5023916678 @default.
• W2051330762 hasAuthorship W2051330762A5036849676 @default.
• W2051330762 hasAuthorship W2051330762A5040860122 @default.
• W2051330762 hasAuthorship W2051330762A5059044821 @default.
• W2051330762 hasAuthorship W2051330762A5085634864 @default.
• W2051330762 hasBestOaLocation W20513307621 @default.
• W2051330762 hasConcept C12554922 @default.
• W2051330762 hasConcept C126322002 @default.
• W2051330762 hasConcept C134018914 @default.
• W2051330762 hasConcept C170493617 @default.
• W2051330762 hasConcept C185592680 @default.
• W2051330762 hasConcept C2775893369 @default.
• W2051330762 hasConcept C2777667214 @default.
• W2051330762 hasConcept C2779547902 @default.
• W2051330762 hasConcept C4141045 @default.
• W2051330762 hasConcept C50254741 @default.
• W2051330762 hasConcept C55493867 @default.
• W2051330762 hasConcept C71240020 @default.
• W2051330762 hasConcept C71924100 @default.
• W2051330762 hasConcept C86803240 @default.
• W2051330762 hasConcept C98274493 @default.
• W2051330762 hasConceptScore W2051330762C12554922 @default.
• W2051330762 hasConceptScore W2051330762C126322002 @default.
• W2051330762 hasConceptScore W2051330762C134018914 @default.
• W2051330762 hasConceptScore W2051330762C170493617 @default.
• W2051330762 hasConceptScore W2051330762C185592680 @default.
• W2051330762 hasConceptScore W2051330762C2775893369 @default.
• W2051330762 hasConceptScore W2051330762C2777667214 @default.
• W2051330762 hasConceptScore W2051330762C2779547902 @default.
• W2051330762 hasConceptScore W2051330762C4141045 @default.
• W2051330762 hasConceptScore W2051330762C50254741 @default.
• W2051330762 hasConceptScore W2051330762C55493867 @default.
• W2051330762 hasConceptScore W2051330762C71240020 @default.
• W2051330762 hasConceptScore W2051330762C71924100 @default.
• W2051330762 hasConceptScore W2051330762C86803240 @default.
• W2051330762 hasConceptScore W2051330762C98274493 @default.
• W2051330762 hasIssue "4" @default.
• W2051330762 hasLocation W20513307621 @default.
• W2051330762 hasLocation W20513307622 @default.
• W2051330762 hasOpenAccess W2051330762 @default.
• W2051330762 hasPrimaryLocation W20513307621 @default.
• W2051330762 hasRelatedWork W1970486150 @default.
• W2051330762 hasRelatedWork W1975576325 @default.
• W2051330762 hasRelatedWork W2057056987 @default.
• W2051330762 hasRelatedWork W2057983183 @default.
• W2051330762 hasRelatedWork W2064710913 @default.
• W2051330762 hasRelatedWork W2092742666 @default.
• W2051330762 hasRelatedWork W2323174039 @default.
• W2051330762 hasRelatedWork W2418873190 @default.

• next