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• W2051352904 abstract "Structural abnormalities of the c-abl proto-oncogene are found in hematopoietic cells of more than 90 percent of individuals with chronic myelogenous leukemia. Therefore c-abl may be important in normal as well as malignant hematopoiesis. Normal human hematopoietic progenitor cells were exposed to three different c-abl sense or antisense oligodeoxynucleotides, and the effects on myeloid and erythroid colony formation were examined. The c-abl antisense oligodeoxynucleotides inhibited myeloid, but not erythroid, colony formation. The c-abl sense oligodeoxynucleotides and bcr sense and antisense oligodeoxynucleotides were not inhibitory in this assay. These data show that c-abl is critical in normal myelopoiesis and may explain the relatively selective expansion of leukocytes in patients with chronic myelogenous leukemia." @default.
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• W2051352904 date "1989-09-08" @default.
• W2051352904 modified "2023-09-27" @default.
• W2051352904 title "Lineage-Specific Requirement of c-<i>abl</i>Function in Normal Hematopoiesis" @default.
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• W2051352904 doi "https://doi.org/10.1126/science.2672339" @default.
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