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- W2051363807 abstract "Differentiation of gastrointestinal lesions such as stenosis, ulcer or polyp is usually performed by endoscopy with multiple biopsies. Nevertheless this differentiation can be difficult and is sometimes impossible. Fluorescence endoscopy (FE) after sensitization with 5-aminolevulinic acid (5-ALA) has shown promising results in the detection of nonvisible precancerous or malignant lesions due to conversion of 5-ALA intracellularly into protoporphyrin IX which accumulates selectively in neoplastic tissue. Illumination with blue light induces a typical red fluorescence. In this study we assessed the clinical value of FE in discriminating visible mucosal abnormalities at the upper and lower gastrointestinal tract with respect to pathologic red fluorescence. Methods: 10 patients with esophageal stenoses and ulcers (=group1), 19 patients with adenomas, ulcers and mucosal abnormalities such as polypoid lesions (=group 2) and 8 patients with colorectal polyps (=group 3) were sensitized with different concentrations of 5-ALA either orally or locally (enema or spraying the mucosa with a catheter). FE was performed 4-6 hours after systemic and 1-2 hours after local sensitization using a special light source (D-light, Storz, Tuttlingen) delivering white and blue light. Biopsies were taken and compared with their fluorescence. Results: The preliminary data indicate, that local sensitization allows discrimination of malignant and benign esophageal stenoses. Differentiation of the remainig malignant and benign visible lesions was not reliable. Conclusion: Proliverative (adenoma) and regenerative (ulcer) tissue are associated with false positive fluorescence which makes differentiation to malignant tissue impossible. However, scarred stensoses of the esophagus can be differentiated with this technique from malignant strictures." @default.
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- W2051363807 date "2000-04-01" @default.
- W2051363807 modified "2023-09-27" @default.
- W2051363807 title "4916 Can fluorescence endoscopy after sensitization with 5-aminolevulinic acid differentiate malignant and benign gastrointestinal lesions?" @default.
- W2051363807 doi "https://doi.org/10.1016/s0016-5107(00)14613-9" @default.
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