Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051383177> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2051383177 endingPage "1312" @default.
- W2051383177 startingPage "1306" @default.
- W2051383177 abstract "Seventy-three patients with disseminated melanoma were given chemotherapy at the University of California Hospitals, San Francisco. The chemotherapeutic regimens employed in their approximate chronological order over the 9-year period were as follows: 1. pyrimidine nucleosides 5-iodo-2'-deoxyridine (IUDR), 5-fluoro-2'-deoxyuridine (FUDR), or a combination of both; 2. alkylating agents, nitrogen mustard, cyclophosphamide, phenylalanine mustard, or chlorambucil; 3. trimethylcolchicinic acid methyl ether d-tartrate (TMCA); 4. a combination of vincristine and cyclophosphamide; 5. a combination of 1, 3 bis (2-chloroethyl)-, l-nitrosourea (BCNU) and vincristine, and 6. a “miscellaneous” group which included hydroxyurea, cytosine arabinoside, and vinblastine. Objective remissions (50% reduction in tumor size) were observed in 6 patients (20%) treated with TMCA and in 1 patient (4%) treated with phenylalanine mustard. Partial responses were observed in 5 patients (17%) treated with TMCA and in 14 patients (19%) treated with other agents. Toxic effects from TMCA (pancytopenia, stomatitis, nausea and vomiting) were rapidly reversed by stopping the drug. In this series, TMCA proved to be a drug which was easily administered, on an outpatient basis, and produced significant remission rates. It is suggested that TMCA receive more extensive drug trials." @default.
- W2051383177 created "2016-06-24" @default.
- W2051383177 creator A5034597556 @default.
- W2051383177 creator A5078733347 @default.
- W2051383177 date "1971-06-01" @default.
- W2051383177 modified "2023-10-16" @default.
- W2051383177 title "Chemotherapy of metastatic malignant melanoma.Experience with 73 patients" @default.
- W2051383177 cites W1979467554 @default.
- W2051383177 cites W2011286356 @default.
- W2051383177 cites W2013510510 @default.
- W2051383177 cites W2020256099 @default.
- W2051383177 cites W2036335876 @default.
- W2051383177 cites W2079741711 @default.
- W2051383177 cites W2418766581 @default.
- W2051383177 doi "https://doi.org/10.1002/1097-0142(197106)27:6<1306::aid-cncr2820270605>3.0.co;2-r" @default.
- W2051383177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4253429" @default.
- W2051383177 hasPublicationYear "1971" @default.
- W2051383177 type Work @default.
- W2051383177 sameAs 2051383177 @default.
- W2051383177 citedByCount "20" @default.
- W2051383177 countsByYear W20513831772015 @default.
- W2051383177 countsByYear W20513831772016 @default.
- W2051383177 crossrefType "journal-article" @default.
- W2051383177 hasAuthorship W2051383177A5034597556 @default.
- W2051383177 hasAuthorship W2051383177A5078733347 @default.
- W2051383177 hasBestOaLocation W20513831771 @default.
- W2051383177 hasConcept C126322002 @default.
- W2051383177 hasConcept C143998085 @default.
- W2051383177 hasConcept C185592680 @default.
- W2051383177 hasConcept C2776694085 @default.
- W2051383177 hasConcept C2776755627 @default.
- W2051383177 hasConcept C2777866208 @default.
- W2051383177 hasConcept C2778670039 @default.
- W2051383177 hasConcept C2778684742 @default.
- W2051383177 hasConcept C2779429289 @default.
- W2051383177 hasConcept C2779434656 @default.
- W2051383177 hasConcept C2780580376 @default.
- W2051383177 hasConcept C2780852908 @default.
- W2051383177 hasConcept C71924100 @default.
- W2051383177 hasConcept C90924648 @default.
- W2051383177 hasConcept C98274493 @default.
- W2051383177 hasConceptScore W2051383177C126322002 @default.
- W2051383177 hasConceptScore W2051383177C143998085 @default.
- W2051383177 hasConceptScore W2051383177C185592680 @default.
- W2051383177 hasConceptScore W2051383177C2776694085 @default.
- W2051383177 hasConceptScore W2051383177C2776755627 @default.
- W2051383177 hasConceptScore W2051383177C2777866208 @default.
- W2051383177 hasConceptScore W2051383177C2778670039 @default.
- W2051383177 hasConceptScore W2051383177C2778684742 @default.
- W2051383177 hasConceptScore W2051383177C2779429289 @default.
- W2051383177 hasConceptScore W2051383177C2779434656 @default.
- W2051383177 hasConceptScore W2051383177C2780580376 @default.
- W2051383177 hasConceptScore W2051383177C2780852908 @default.
- W2051383177 hasConceptScore W2051383177C71924100 @default.
- W2051383177 hasConceptScore W2051383177C90924648 @default.
- W2051383177 hasConceptScore W2051383177C98274493 @default.
- W2051383177 hasIssue "6" @default.
- W2051383177 hasLocation W20513831771 @default.
- W2051383177 hasLocation W20513831772 @default.
- W2051383177 hasOpenAccess W2051383177 @default.
- W2051383177 hasPrimaryLocation W20513831771 @default.
- W2051383177 hasRelatedWork W1979130534 @default.
- W2051383177 hasRelatedWork W1980644216 @default.
- W2051383177 hasRelatedWork W1987216361 @default.
- W2051383177 hasRelatedWork W2029067093 @default.
- W2051383177 hasRelatedWork W2060816095 @default.
- W2051383177 hasRelatedWork W2064663008 @default.
- W2051383177 hasRelatedWork W2080555893 @default.
- W2051383177 hasRelatedWork W2407818252 @default.
- W2051383177 hasRelatedWork W2412301437 @default.
- W2051383177 hasRelatedWork W2580793673 @default.
- W2051383177 hasVolume "27" @default.
- W2051383177 isParatext "false" @default.
- W2051383177 isRetracted "false" @default.
- W2051383177 magId "2051383177" @default.
- W2051383177 workType "article" @default.