FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051427881> ?p ?o ?g. }

• W2051427881 endingPage "594" @default.
• W2051427881 startingPage "589" @default.
• W2051427881 abstract "The fetal liver is the primary site of fetal serine production. The regulation of this unique fetal hepatic serine production is unknown. We hypothesized that serine production would be responsive to folate cofactor supply or hormonal regulation. To test this hypothesis, we determined the effect of key folate cofactors and insulin and glucagon on serine and glycine metabolism in primary culture of fetal ovine hepatocytes. Hepatocytes were cultured in serum-free, low-folate media [5 nM 5-methyl-tetrahydrofolate (THF)] with or without 50 nM 5,10-methylene-THF (MTHF) or 5-formyl-THF (FTHF). Serine and glycine production (P) and utilization (U) were determined by stable isotope dilution with [1-(13)C]serine and [1-(13)C]glycine for 24 h. The effect of insulin (1 microM) or glucagon (1 micro M) was determined in a similar manner. Under basal conditions, serine P (43.2 +/- 5.1 micromol/mg DNA per 24 h) is greater than serine U (24.1 +/- 3.1 micromol/mg DNA per 24 h), whereas glycine U (27.3 +/- 3.0 micromol/mg DNA per 24 h) exceeds glycine P (16.7 +/- 1.9 micromol/mg DNA per 24 h). MTHF results in a significant decrease in serine U (16.0 +/- 2.7 micromol/mg DNA per 24 h; p = 0.02 versus low folate), with no change in serine P. FTHF reduces serine P (36.2 +/- 4.9 micromol/mg DNA per 24 h; p = 0.01), but does not alter serine U. There were no effects on glycine metabolism with 50 nM MTHF or FTHF. Serine P and U were inversely correlated whereas glycine P and U were directly correlated with the media concentration of MTHF or FTHF. Glucagon treatment increased serine U by 260 +/- 65% versus low folate (p = 0.0004) but did not change serine P. Insulin treatment led to parallel increases in both serine P and U. Both folate cofactor availability and hormone concentrations regulate serine metabolism in the fetal liver. We speculate that serine metabolism may be a marker of fetal hepatic folate cofactor supply." @default.
• W2051427881 created "2016-06-24" @default.
• W2051427881 creator A5000937196 @default.
• W2051427881 creator A5022713370 @default.
• W2051427881 creator A5029882384 @default.
• W2051427881 creator A5046466058 @default.
• W2051427881 creator A5072308485 @default.
• W2051427881 date "2002-10-01" @default.
• W2051427881 modified "2023-10-18" @default.
• W2051427881 title "Folate Cofactors Regulate Serine Metabolism in Fetal Ovine Hepatocytes" @default.
• W2051427881 cites W123012959 @default.
• W2051427881 cites W1485977198 @default.
• W2051427881 cites W1562169645 @default.
• W2051427881 cites W1673653510 @default.
• W2051427881 cites W1775749144 @default.
• W2051427881 cites W1963860577 @default.
• W2051427881 cites W1969825843 @default.
• W2051427881 cites W1971409723 @default.
• W2051427881 cites W1976949788 @default.
• W2051427881 cites W1977779461 @default.
• W2051427881 cites W1991992622 @default.
• W2051427881 cites W1994730745 @default.
• W2051427881 cites W2000497722 @default.
• W2051427881 cites W2014281089 @default.
• W2051427881 cites W2023476087 @default.
• W2051427881 cites W2031950585 @default.
• W2051427881 cites W2037972689 @default.
• W2051427881 cites W2048316852 @default.
• W2051427881 cites W2063515916 @default.
• W2051427881 cites W2074418450 @default.
• W2051427881 cites W2085276239 @default.
• W2051427881 cites W2089962821 @default.
• W2051427881 cites W2112287556 @default.
• W2051427881 cites W2134199477 @default.
• W2051427881 cites W2323026550 @default.
• W2051427881 cites W2336826357 @default.
• W2051427881 cites W97951305 @default.
• W2051427881 doi "https://doi.org/10.1203/00006450-200210000-00020" @default.
• W2051427881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12357055" @default.
• W2051427881 hasPublicationYear "2002" @default.
• W2051427881 type Work @default.
• W2051427881 sameAs 2051427881 @default.
• W2051427881 citedByCount "7" @default.
• W2051427881 countsByYear W20514278812012 @default.
• W2051427881 countsByYear W20514278812020 @default.
• W2051427881 countsByYear W20514278812022 @default.
• W2051427881 countsByYear W20514278812023 @default.
• W2051427881 crossrefType "journal-article" @default.
• W2051427881 hasAuthorship W2051427881A5000937196 @default.
• W2051427881 hasAuthorship W2051427881A5022713370 @default.
• W2051427881 hasAuthorship W2051427881A5029882384 @default.
• W2051427881 hasAuthorship W2051427881A5046466058 @default.
• W2051427881 hasAuthorship W2051427881A5072308485 @default.
• W2051427881 hasBestOaLocation W20514278811 @default.
• W2051427881 hasConcept C11960822 @default.
• W2051427881 hasConcept C126322002 @default.
• W2051427881 hasConcept C134018914 @default.
• W2051427881 hasConcept C160560785 @default.
• W2051427881 hasConcept C181199279 @default.
• W2051427881 hasConcept C185592680 @default.
• W2051427881 hasConcept C197957613 @default.
• W2051427881 hasConcept C2776414213 @default.
• W2051427881 hasConcept C2777756961 @default.
• W2051427881 hasConcept C2778563252 @default.
• W2051427881 hasConcept C2779306644 @default.
• W2051427881 hasConcept C515207424 @default.
• W2051427881 hasConcept C55493867 @default.
• W2051427881 hasConcept C62231903 @default.
• W2051427881 hasConcept C71924100 @default.
• W2051427881 hasConcept C86803240 @default.
• W2051427881 hasConceptScore W2051427881C11960822 @default.
• W2051427881 hasConceptScore W2051427881C126322002 @default.
• W2051427881 hasConceptScore W2051427881C134018914 @default.
• W2051427881 hasConceptScore W2051427881C160560785 @default.
• W2051427881 hasConceptScore W2051427881C181199279 @default.
• W2051427881 hasConceptScore W2051427881C185592680 @default.
• W2051427881 hasConceptScore W2051427881C197957613 @default.
• W2051427881 hasConceptScore W2051427881C2776414213 @default.
• W2051427881 hasConceptScore W2051427881C2777756961 @default.
• W2051427881 hasConceptScore W2051427881C2778563252 @default.
• W2051427881 hasConceptScore W2051427881C2779306644 @default.
• W2051427881 hasConceptScore W2051427881C515207424 @default.
• W2051427881 hasConceptScore W2051427881C55493867 @default.
• W2051427881 hasConceptScore W2051427881C62231903 @default.
• W2051427881 hasConceptScore W2051427881C71924100 @default.
• W2051427881 hasConceptScore W2051427881C86803240 @default.
• W2051427881 hasIssue "4" @default.
• W2051427881 hasLocation W20514278811 @default.
• W2051427881 hasLocation W20514278812 @default.
• W2051427881 hasOpenAccess W2051427881 @default.
• W2051427881 hasPrimaryLocation W20514278811 @default.
• W2051427881 hasRelatedWork W1533751437 @default.
• W2051427881 hasRelatedWork W1535356922 @default.
• W2051427881 hasRelatedWork W1749748096 @default.
• W2051427881 hasRelatedWork W1983914873 @default.
• W2051427881 hasRelatedWork W2000016162 @default.
• W2051427881 hasRelatedWork W2019526738 @default.
• W2051427881 hasRelatedWork W2076338086 @default.

• next