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• W2051434583 endingPage "173" @default.
• W2051434583 startingPage "166" @default.
• W2051434583 abstract "In the present study, the possible effect of nitric oxide agents injected into the nucleus accumbens (NAc) in the presence or absence of nicotine on morphine state-dependent memory in adult male Wistar rats was investigated. As a model of memory, a step-through type inhibitory avoidance task was used. Post-training injection of morphine (4 and 6mg/kg) dose dependently induced the impairment of memory retention. Administration of morphine (4 and 6mg/kg) before retention induced state-dependent retrieval of the memory acquired under post-training morphine (6mg/kg) influence. Injection of nicotine before retention (0.25 and 0.5mg/kg) alone and nicotine (0.1, 0.25 and 0.5mg/kg) plus an ineffective dose of morphine (2mg/kg) reversed the post-training morphine-induced memory impairment. The amnesia elicited by morphine (6mg/kg) was also prevented by pre-retention intra-NAc administration of a nitric oxide synthase (NOS) inhibitor, l-NAME (0.24μg/rat, intra-NAc). Interestingly, an ineffective dose of nicotine (0.1mg/kg) in combination with low doses of l-NAME (0.06 and 0.12μg/rat, intra-NAc) synergistically improved memory performance impaired by morphine given after training. It is important to note that intra-NAc administration of l-NAME before retention impaired memory retrieval by itself. In contrast, pre-retention administration of l-arginine, a nitric oxide (NO) precursor (0.25 and 0.5μg/rat, intra-NAc), which had no effect alone, prevented the nicotine reversal of morphine effect on memory. The results suggest a possible role for nitric oxide of nucleus accumbens in the improving effect of nicotine on the morphine-induced amnesia and morphine state-dependent memory." @default.
• W2051434583 created "2016-06-24" @default.
• W2051434583 creator A5004772033 @default.
• W2051434583 creator A5032744675 @default.
• W2051434583 creator A5034350764 @default.
• W2051434583 creator A5069840884 @default.
• W2051434583 date "2012-03-01" @default.
• W2051434583 modified "2023-09-26" @default.
• W2051434583 title "Nitric oxide in the nucleus accumbens is involved in retrieval of inhibitory avoidance memory by nicotine" @default.
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• W2051434583 doi "https://doi.org/10.1016/j.pbb.2011.11.010" @default.
• W2051434583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22133634" @default.
• W2051434583 hasPublicationYear "2012" @default.

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