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- W2051444314 abstract "Candida albicans is a commensal organism of the human gastrointestinal and genitourinary systems as well as the most common human fungal pathogen [1]. The organism causes mucosal infections such as oropharyngeal or vulvo-vaginal candidiasis, but it can also cause life-threatening invasive disease. Healthy individuals readily maintain the organism in its commensal state but individuals with defects in the anti–C. albicans immune response are at high risk for developing disease. Phagocytes, particularly macrophages and neutrophils, are critical to the host's ability to prevent invasive candidiasis [2].C. albicans poses a particular challenge to host defenses because it is polymorphic; round yeast forms and filamentous pseudohyphae and hyphae forms are all present during infection [3], [4]. Yeast and filamentous C. albicans have a number of important physiological, structural, and biochemical differences. Accordingly, the immune response to these forms differs substantially [4], [5]. The type of recognition receptors used to detect C. albicans, as well as the phagocyte type, anatomic site of infection, and course of infection, all serve to modulate the host response to the organism [2], [6]. Macrophages are particularly important because they can both limit C. albicans burden early in infection and recruit and activate other immune effector cells [4], [6]. Our understanding of the mechanisms and consequences of the interaction between macrophages and C. albicans is improving, but much remains to be learned." @default.
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- W2051444314 date "2014-06-26" @default.
- W2051444314 modified "2023-10-16" @default.
- W2051444314 title "Catching Fire: Candida albicans, Macrophages, and Pyroptosis" @default.
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- W2051444314 doi "https://doi.org/10.1371/journal.ppat.1004139" @default.
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