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• W2051444778 abstract "In the investigation of a chemical reaction, researchers typically survey variables such as time, temperature, and stoichiometry to optimize yields. This Account demonstrates how control of these variables, often in nontraditional ways, can provide significant improvements in enantiomeric ratios for asymmetric reactions. Dynamic thermodynamic resolution (DTR) offers a convenient method for the resolution of enantiomeric products in the course of a reaction. This process depends on an essential requirement: the equilibration of the penultimate diastereomers must be subject to external control. As a general case, the reaction of AR, AS with B under the influence of the chiral species, L*, gives resolved products CR and CS. In the first step of dynamic resolution under thermodynamic control, the enantiomeric reactants AR and AS and L* form the diastereomers AR/L* and AS/L*. The equilibrium between AR and AS can be rapid, slow, or not operative, and L* can represent a ligand, an auxiliary, or a crystallization process that provides a chiral environment. Second, the populations of the diastereomers are controlled, usually by thermal equilibration. Finally, the reaction of the diastereomers with a reagent B provides the enantiomeric products CR and CS. The control of the diastereomeric equilibrium distinguishes DTR from other resolution techniques. By contrast, physical resolutions separate thermodynamically stable, nonequilibrating diastereomers, and dynamic kinetic resolutions utilize kinetic control for reactions of rapidly equilibrating diastereomers. The dynamic thermodynamic resolutions discussed in this Account illustrate cases of significantly improved enantioselectivities using this technique. Although many of the well-recognized cases come from organolithium chemistry, the principles are general, and we also present cases facilitated by other chemistries. This approach has been used to control enantioselectivities in a number of different reactions, with improvements in enantiomeric ratios up to 99% from essentially racemic reactants." @default.
• W2051444778 created "2016-06-24" @default.
• W2051444778 creator A5046637540 @default.
• W2051444778 creator A5072926516 @default.
• W2051444778 creator A5091398220 @default.
• W2051444778 date "2009-01-16" @default.
• W2051444778 modified "2023-10-16" @default.
• W2051444778 title "Dynamic Thermodynamic Resolution: Advantage by Separation of Equilibration and Resolution" @default.
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• W2051444778 doi "https://doi.org/10.1021/ar8000662" @default.
• W2051444778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19152329" @default.
• W2051444778 hasPublicationYear "2009" @default.
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