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- W2051445811 abstract "A cyclic GMP-dependent protein kinase, which catalyzes the phosphorylation of histones and protamine by ATP, was present together with a cyclic AMP-dependent protein kinase and a readily active protein kinase in the rat pancreas. These three protein kinases were separated by chromatography on DEAE-cellulose. The cyclic GMP-dependent protein kinase was relatively cationic and fragile. Upon activation by cyclic GMP, this kinase dissociated into a light catalytic subunit and a somewhat heavier cyclic GMP binding subunit. A crude 27,000 × g pancreas supernatant had two apparent Ka values for cyclic GMP of 2.10−8 M and 3.10−7 M. The possible relationships between protein kinases and enzyme secretion are discussed." @default.
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- W2051445811 date "1973-09-01" @default.
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- W2051445811 title "Cyclic nucleotide-dependent protein kinases of the rat pancreas" @default.
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- W2051445811 doi "https://doi.org/10.1016/0006-291x(73)90906-6" @default.
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