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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051445852> ?p ?o ?g. }

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• W2051445852 abstract "Bacterial adhesion to glycosylated surfaces is a key issue in human health and disease. Inhibition of bacterial adhesion by suitable carbohydrates could lead to an anti-adhesion therapy as a novel approach against bacterial infections. A selection of five α-mannosides has been evaluated as inhibitors of bacterial adhesion to the polysaccharide mannan, as well as to the surface of live human HT-29 cells. Cell toxicity studies were performed to identify the therapeutic window for a potential in vivo-application of the tested carbohydrates. A previously published mannosidic squaric acid diamide was shown to be exceptionally effective as inhibitor of the bacterial lectin FimH." @default.
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• W2051445852 date "2012-04-10" @default.
• W2051445852 modified "2023-09-29" @default.
• W2051445852 title "Inhibition of bacterial adhesion to live human cells: Activity and cytotoxicity of synthetic mannosides" @default.
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• W2051445852 doi "https://doi.org/10.1016/j.febslet.2012.03.059" @default.
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