Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051451130> ?p ?o ?g. }
- W2051451130 endingPage "486" @default.
- W2051451130 startingPage "483" @default.
- W2051451130 abstract "In the surgical neonate, three factors that promote bacterial translocation and systemic infection are: (1) intestinal bacterial colonization and overgrowth; (2) compromised host defenses; and (3) disruption of the mucosal epithelial barrier. The newborn rabbit provides an excellent model to study these factors. Like the human, there is early closure of the gut mucosa to macromolecules, and nutrition can be maintained by breast or formula feeding. This study examines translocation and systemic sepsis after colonization with virulent K1 and avirulent K100 strains of Escherichia coli. New Zealand white rabbit pups (2 to 5 days old) were studied. The gastrointestinal tracts of 12 were colonized with K1 E coli; 14 were colonized with K100 E coli; 12 control animals were not inoculated. Mesenteric lymph node (MLN), liver, spleen, and colon homogenate were cultured 72 hours postinoculation. No bacteria were isolated from the colons of all but one control animal. Translocation or systemic sepsis did not occur. Translocation to the MLN was significantly increased (P < .03) in K1 (50%) and K100 (36%) groups compared with controls (0%). Translocation to liver and spleen (systemic sepsis) was significantly increased (P < .03) in K1 animals (67%) compared with K100 (0%) or controls (0%). Colonization by both strains of E coli led to translocation to the MLN, but only K1 E coli caused systemic sepsis. This suggests that although colonization by E coli in the newborn leads to translocation to the MLN, progression to systemic sepsis is the result of characteristics of the bacteria and/or neonatal host responses." @default.
- W2051451130 created "2016-06-24" @default.
- W2051451130 creator A5004070919 @default.
- W2051451130 creator A5008218354 @default.
- W2051451130 creator A5018600373 @default.
- W2051451130 creator A5024215519 @default.
- W2051451130 creator A5074389432 @default.
- W2051451130 date "1991-04-01" @default.
- W2051451130 modified "2023-09-23" @default.
- W2051451130 title "The effect of E coli virulence on bacterial translocation and systemic sepsis in the neonatal rabbit model" @default.
- W2051451130 cites W1692894082 @default.
- W2051451130 cites W1846461377 @default.
- W2051451130 cites W1905885715 @default.
- W2051451130 cites W1936658752 @default.
- W2051451130 cites W1961727790 @default.
- W2051451130 cites W1986147894 @default.
- W2051451130 cites W2007987404 @default.
- W2051451130 cites W2017905293 @default.
- W2051451130 cites W2038502009 @default.
- W2051451130 cites W2050490859 @default.
- W2051451130 cites W2078508999 @default.
- W2051451130 cites W2100862733 @default.
- W2051451130 cites W2410645950 @default.
- W2051451130 cites W2941087694 @default.
- W2051451130 doi "https://doi.org/10.1016/0022-3468(91)91000-o" @default.
- W2051451130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2056412" @default.
- W2051451130 hasPublicationYear "1991" @default.
- W2051451130 type Work @default.
- W2051451130 sameAs 2051451130 @default.
- W2051451130 citedByCount "19" @default.
- W2051451130 countsByYear W20514511302020 @default.
- W2051451130 crossrefType "journal-article" @default.
- W2051451130 hasAuthorship W2051451130A5004070919 @default.
- W2051451130 hasAuthorship W2051451130A5008218354 @default.
- W2051451130 hasAuthorship W2051451130A5018600373 @default.
- W2051451130 hasAuthorship W2051451130A5024215519 @default.
- W2051451130 hasAuthorship W2051451130A5074389432 @default.
- W2051451130 hasConcept C104317684 @default.
- W2051451130 hasConcept C138626823 @default.
- W2051451130 hasConcept C145081991 @default.
- W2051451130 hasConcept C203014093 @default.
- W2051451130 hasConcept C2775953899 @default.
- W2051451130 hasConcept C2776252253 @default.
- W2051451130 hasConcept C2776914184 @default.
- W2051451130 hasConcept C2776927270 @default.
- W2051451130 hasConcept C2778384902 @default.
- W2051451130 hasConcept C2779237934 @default.
- W2051451130 hasConcept C2779959462 @default.
- W2051451130 hasConcept C2780917455 @default.
- W2051451130 hasConcept C2780931953 @default.
- W2051451130 hasConcept C523546767 @default.
- W2051451130 hasConcept C54355233 @default.
- W2051451130 hasConcept C547475151 @default.
- W2051451130 hasConcept C55493867 @default.
- W2051451130 hasConcept C60987743 @default.
- W2051451130 hasConcept C71924100 @default.
- W2051451130 hasConcept C86803240 @default.
- W2051451130 hasConcept C89423630 @default.
- W2051451130 hasConceptScore W2051451130C104317684 @default.
- W2051451130 hasConceptScore W2051451130C138626823 @default.
- W2051451130 hasConceptScore W2051451130C145081991 @default.
- W2051451130 hasConceptScore W2051451130C203014093 @default.
- W2051451130 hasConceptScore W2051451130C2775953899 @default.
- W2051451130 hasConceptScore W2051451130C2776252253 @default.
- W2051451130 hasConceptScore W2051451130C2776914184 @default.
- W2051451130 hasConceptScore W2051451130C2776927270 @default.
- W2051451130 hasConceptScore W2051451130C2778384902 @default.
- W2051451130 hasConceptScore W2051451130C2779237934 @default.
- W2051451130 hasConceptScore W2051451130C2779959462 @default.
- W2051451130 hasConceptScore W2051451130C2780917455 @default.
- W2051451130 hasConceptScore W2051451130C2780931953 @default.
- W2051451130 hasConceptScore W2051451130C523546767 @default.
- W2051451130 hasConceptScore W2051451130C54355233 @default.
- W2051451130 hasConceptScore W2051451130C547475151 @default.
- W2051451130 hasConceptScore W2051451130C55493867 @default.
- W2051451130 hasConceptScore W2051451130C60987743 @default.
- W2051451130 hasConceptScore W2051451130C71924100 @default.
- W2051451130 hasConceptScore W2051451130C86803240 @default.
- W2051451130 hasConceptScore W2051451130C89423630 @default.
- W2051451130 hasIssue "4" @default.
- W2051451130 hasLocation W20514511301 @default.
- W2051451130 hasLocation W20514511302 @default.
- W2051451130 hasOpenAccess W2051451130 @default.
- W2051451130 hasPrimaryLocation W20514511301 @default.
- W2051451130 hasRelatedWork W2006404825 @default.
- W2051451130 hasRelatedWork W2045070223 @default.
- W2051451130 hasRelatedWork W2051451130 @default.
- W2051451130 hasRelatedWork W2061297944 @default.
- W2051451130 hasRelatedWork W2087887478 @default.
- W2051451130 hasRelatedWork W2318106903 @default.
- W2051451130 hasRelatedWork W2561642321 @default.
- W2051451130 hasRelatedWork W2739219804 @default.
- W2051451130 hasRelatedWork W2992961870 @default.
- W2051451130 hasRelatedWork W3217740760 @default.
- W2051451130 hasVolume "26" @default.
- W2051451130 isParatext "false" @default.
- W2051451130 isRetracted "false" @default.
- W2051451130 magId "2051451130" @default.