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- W2051451570 startingPage "e1004175" @default.
- W2051451570 abstract "Loss-of-function mutations in the Caenorhabditis elegans gene sup-18 suppress the defects in muscle contraction conferred by a gain-of-function mutation in SUP-10, a presumptive regulatory subunit of the SUP-9 two-pore domain K(+) channel associated with muscle membranes. We cloned sup-18 and found that it encodes the C. elegans ortholog of mammalian iodotyrosine deiodinase (IYD), an NADH oxidase/flavin reductase that functions in iodine recycling and is important for the biosynthesis of thyroid hormones that regulate metabolism. The FMN-binding site of mammalian IYD is conserved in SUP-18, which appears to require catalytic activity to function. Genetic analyses suggest that SUP-10 can function with SUP-18 to activate SUP-9 through a pathway that is independent of the presumptive SUP-9 regulatory subunit UNC-93. We identified a novel evolutionarily conserved serine-cysteine-rich region in the C-terminal cytoplasmic domain of SUP-9 required for its specific activation by SUP-10 and SUP-18 but not by UNC-93. Since two-pore domain K(+) channels regulate the resting membrane potentials of numerous cell types, we suggest that the SUP-18 IYD regulates the activity of the SUP-9 channel using NADH as a coenzyme and thus couples the metabolic state of muscle cells to muscle membrane excitability." @default.
- W2051451570 created "2016-06-24" @default.
- W2051451570 creator A5036611540 @default.
- W2051451570 creator A5062169826 @default.
- W2051451570 creator A5075093223 @default.
- W2051451570 date "2014-02-20" @default.
- W2051451570 modified "2023-09-27" @default.
- W2051451570 title "The Caenorhabditis elegans Iodotyrosine Deiodinase Ortholog SUP-18 Functions through a Conserved Channel SC-Box to Regulate the Muscle Two-Pore Domain Potassium Channel SUP-9" @default.
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- W2051451570 doi "https://doi.org/10.1371/journal.pgen.1004175" @default.
- W2051451570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3930498" @default.
- W2051451570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24586202" @default.
- W2051451570 hasPublicationYear "2014" @default.
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