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- W2051456247 abstract "In patients with severe coronary artery disease a systemic inflammatory reaction (SIRS) occurs that contributes to thrombotic complications. To evaluate the systemic inflammatory response in patients with coronary stent implantation, serial venous blood samples were taken in 101 patients before and after stent implantation. Humoral and cellular inflammatory markers as well as the prothrombin-fragments F1 + 2 were analysed. An initial elevated thrombin generation was followed by an increased integrin surface expression (CD11 b, FACScan) on monocytes (Mo) and granulocytes (PMN) (plateau after 2 days) and by an increase in plasma fibrinogen (fbg) and C-reactive protein (CRP) (plateau after 5 days). The initial Fl + 2 peak correlated significantly with fbg and CRP at day 5 (r = 0.07 and 0.31, p = 0.0001) and with CD11 b surface expression on Mo at day 2 (r = 0.02, P < 0.05) and on PMN by trend (p < 0.1).Download : Download high-res image (80KB)Download : Download full-size image After coronary stent implantation a systemic inflammatory reaction occurs. Its extend may have a causative relationship to the thrombin generation during stent implantation." @default.
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- W2051456247 date "1995-02-01" @default.
- W2051456247 modified "2023-10-18" @default.
- W2051456247 title "967-22 Thrombin Generation and Systemic Inflammatory Response After Coronary Stent Implantation" @default.
- W2051456247 doi "https://doi.org/10.1016/0735-1097(95)92456-f" @default.
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