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• W2051480474 abstract "We investigated the effects of ATP (adenosine 5′-triphosphate) and derivatives on leech neuropile glial cells, focusing on exposed glial cells. ATP dose-dependently depolarized or hyperpolarized neuropile glial cells in situ as well as exposed neuropile glial cells. These potential shifts varied among cells and repetitive ATP application did not change their amplitude, duration or direction. In exposed neuropile glial cells, ATP most frequently induced a Na+-dependent depolarization and decreased the input resistance. The agonist potency ATP > ADP (adenosine 5′-diphosphate) > AMP (adenosine 5′-monophosphate) > adenosine indicates that P2 purinoceptors mediate this depolarization. The P2Y agonist 2-methylthio-ATP mimicked the ATP-induced depolarization, whereas the P2Y antagonist PPADS (pyridoxal-phosphate-6-azophenyl-2′,4′-disulphonic acid) reduced it. P2X agonists were without effect. Because the P1 antagonist 8-SPT (8-(p-sulphophenyl)-theophylline) also depressed ATP-induced depolarizations and some ATP-insensitive glial cells responded to adenosine, we suggest coexpression of metabotropic P2Y and P1 purinoceptors. The ATP-induced depolarization requires activation of Na+ channels or nonselective cation channels, whereas the ATP-induced hyperpolarization indicates activation of K+ channels. ATP also increased the intracellular Ca2+ concentration ([Ca2+]i), that is independent of Ca2+ influx but reflects intracellular Ca2+ release possibly triggered by IP3 formation. ADP and AMP also increased [Ca2+]i, but were less efficient than ATP; adenosine and 2-methylthio-ATP did not affect [Ca2+]i. In view of the mobilization of intracellular Ca2+, ATP is clearly different from other leech neurotransmitters, because it enables intracellular Ca2+ signaling without causing prominent changes in glial membrane potential. Thus disturbance of the extracellular microenvironment and the demand for metabolic energy are minimized. GLIA 29:191–201, 2000. © 2000 Wiley-Liss, Inc." @default.
• W2051480474 created "2016-06-24" @default.
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• W2051480474 date "2000-02-01" @default.
• W2051480474 modified "2023-09-27" @default.
• W2051480474 title "Effects of ATP and derivatives on neuropile glial cells of the leech central nervous system" @default.
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• W2051480474 doi "https://doi.org/10.1002/(sici)1098-1136(20000201)29:3<191::aid-glia1>3.0.co;2-r" @default.
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