FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051482261> ?p ?o ?g. }

• W2051482261 endingPage "251" @default.
• W2051482261 startingPage "237" @default.
• W2051482261 abstract "Regulation of intracellular pH (pHi) was investigated in Trypanosoma cruzi amastigotes and trypomastigotes using 2',7'-bis-(carboxyethyl)-5(and-6)-carboxyfluorescein (BCECF). pHi was determined to be 7.33 +/- 0.08 and 7.35 +/- 0.07 in amastigotes and trypomastigotes, respectively, and there were no significant differences in the regulation of pH, between the two stages. Steady-state pHi, recovery of pHi from acidification, and H+-efflux were all decreased markedly by the H+-ATPase inhibitors N,N'-dicyclohexylcarbodi-imide (DCCD), diethylstilbestrol (DES) and N-ethylmaleimide (NEM) supporting a significant role for a plasma membrane H+-ATPase in the regulation of pHi. pHi was maintained at neutrality over a range of external pH (pHe) from 5-8 in parasites suspended in a buffer containing Na+ and K+ (standard buffer) but was acidified at low pHe in the absence of these cations (choline buffer). The pHi of trypomastigotes decreased significantly when they transformed into amastigotes. The rate of recovery of pHi by acidified parasites was similar in Na+-free buffer and standard buffer but was slower in the absence of K+ (K+-free or choline buffer) and parasites suspended in choline buffer were acidic by 0.25 pH units as compared with controls. Ba2+ and Cs+ decreased the pHi of parasites suspended in standard but not choline buffer suggesting the presence of an inward directed K+ channel. The pHi of amastigotes and trypomastigotes suspended in Cl(-)-free buffer was decreased by 0.13 and 0.2 pH units, respectively, supporting the presence of a chloride conductive channel. No evidence of pH regulation via a Na+/H+ or Cl-/HCO3- exchanger was found. These results are consistent with the presence of a plasma membrane H+-ATPase that regulates pHi and is supported by K+ and Cl- channels." @default.
• W2051482261 created "2016-06-24" @default.
• W2051482261 creator A5000842323 @default.
• W2051482261 creator A5012616385 @default.
• W2051482261 date "2000-02-01" @default.
• W2051482261 modified "2023-09-27" @default.
• W2051482261 title "Intracellular pH in mammalian stages of Trypanosoma cruzi is K+-dependent and regulated by H+-ATPases" @default.
• W2051482261 cites W1570727454 @default.
• W2051482261 cites W1652327382 @default.
• W2051482261 cites W1965828139 @default.
• W2051482261 cites W1984020576 @default.
• W2051482261 cites W1987117313 @default.
• W2051482261 cites W2015242911 @default.
• W2051482261 cites W2020052670 @default.
• W2051482261 cites W2025838739 @default.
• W2051482261 cites W2028263525 @default.
• W2051482261 cites W2030299263 @default.
• W2051482261 cites W2031183620 @default.
• W2051482261 cites W2031587970 @default.
• W2051482261 cites W2036648344 @default.
• W2051482261 cites W2037088393 @default.
• W2051482261 cites W2042171606 @default.
• W2051482261 cites W2044648061 @default.
• W2051482261 cites W2044966710 @default.
• W2051482261 cites W2049812842 @default.
• W2051482261 cites W2056648333 @default.
• W2051482261 cites W2064327313 @default.
• W2051482261 cites W2067536391 @default.
• W2051482261 cites W2069583608 @default.
• W2051482261 cites W2073266157 @default.
• W2051482261 cites W2092284382 @default.
• W2051482261 cites W2113002362 @default.
• W2051482261 cites W2113076036 @default.
• W2051482261 cites W2117683643 @default.
• W2051482261 cites W2121746118 @default.
• W2051482261 cites W2124381559 @default.
• W2051482261 cites W2153771719 @default.
• W2051482261 cites W2156677955 @default.
• W2051482261 cites W2353284941 @default.
• W2051482261 cites W2408230080 @default.
• W2051482261 cites W2418106596 @default.
• W2051482261 cites W4304688027 @default.
• W2051482261 doi "https://doi.org/10.1016/s0166-6851(99)00184-x" @default.
• W2051482261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10693746" @default.
• W2051482261 hasPublicationYear "2000" @default.
• W2051482261 type Work @default.
• W2051482261 sameAs 2051482261 @default.
• W2051482261 citedByCount "33" @default.
• W2051482261 countsByYear W20514822612012 @default.
• W2051482261 countsByYear W20514822612013 @default.
• W2051482261 countsByYear W20514822612015 @default.
• W2051482261 countsByYear W20514822612017 @default.
• W2051482261 countsByYear W20514822612019 @default.
• W2051482261 countsByYear W20514822612020 @default.
• W2051482261 countsByYear W20514822612021 @default.
• W2051482261 countsByYear W20514822612022 @default.
• W2051482261 countsByYear W20514822612023 @default.
• W2051482261 crossrefType "journal-article" @default.
• W2051482261 hasAuthorship W2051482261A5000842323 @default.
• W2051482261 hasAuthorship W2051482261A5012616385 @default.
• W2051482261 hasConcept C12554922 @default.
• W2051482261 hasConcept C134897140 @default.
• W2051482261 hasConcept C136764020 @default.
• W2051482261 hasConcept C181199279 @default.
• W2051482261 hasConcept C185592680 @default.
• W2051482261 hasConcept C190283241 @default.
• W2051482261 hasConcept C203522944 @default.
• W2051482261 hasConcept C23265538 @default.
• W2051482261 hasConcept C2777722557 @default.
• W2051482261 hasConcept C2778117296 @default.
• W2051482261 hasConcept C2781092759 @default.
• W2051482261 hasConcept C2781123555 @default.
• W2051482261 hasConcept C28406088 @default.
• W2051482261 hasConcept C41008148 @default.
• W2051482261 hasConcept C43617362 @default.
• W2051482261 hasConcept C55493867 @default.
• W2051482261 hasConcept C71928629 @default.
• W2051482261 hasConcept C79879829 @default.
• W2051482261 hasConcept C86803240 @default.
• W2051482261 hasConcept C98319499 @default.
• W2051482261 hasConceptScore W2051482261C12554922 @default.
• W2051482261 hasConceptScore W2051482261C134897140 @default.
• W2051482261 hasConceptScore W2051482261C136764020 @default.
• W2051482261 hasConceptScore W2051482261C181199279 @default.
• W2051482261 hasConceptScore W2051482261C185592680 @default.
• W2051482261 hasConceptScore W2051482261C190283241 @default.
• W2051482261 hasConceptScore W2051482261C203522944 @default.
• W2051482261 hasConceptScore W2051482261C23265538 @default.
• W2051482261 hasConceptScore W2051482261C2777722557 @default.
• W2051482261 hasConceptScore W2051482261C2778117296 @default.
• W2051482261 hasConceptScore W2051482261C2781092759 @default.
• W2051482261 hasConceptScore W2051482261C2781123555 @default.
• W2051482261 hasConceptScore W2051482261C28406088 @default.
• W2051482261 hasConceptScore W2051482261C41008148 @default.
• W2051482261 hasConceptScore W2051482261C43617362 @default.
• W2051482261 hasConceptScore W2051482261C55493867 @default.
• W2051482261 hasConceptScore W2051482261C71928629 @default.
• W2051482261 hasConceptScore W2051482261C79879829 @default.

• next