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• W2051493108 abstract "A double‐blind, placebo‐controlled study was carried out in 85 patients with a well‐documented history of perennial asthma caused by house‐dust mites. Patients received either placebo or sublingual immunotherapy (SLIT) with a standardized Dermatophagoides pteronyssinus (DP)– D. farinae (DF) 50/50 extract. After a run‐in period, patients received increasing doses up to 300 IR every day for 4 weeks and then three times a week for the following 24 months. The cumulative dose was about 104 000 IR, equivalent to 4.2 mg Der p 1 and 7.3 mg Der f 1. Symptom and medication scores and respiratory function were assessed throughout the trial. Serum specific IgE and IgG4 were determined before SLIT ( t 0 ) and after 6 ( t 1 ), 11 ( t 2 ), 17 ( t 3 ), and 25 months ( t 4 ) of SLIT. Mite exposure was evaluated at t 0 , t 2 , and t 4 by semiquantitative guanine determinations. Patients aged 15 years and older were asked to assess their quality of life (QoL) by completing the SF20 (Short Form Health Status Survey) plus two items at t 0 , t 2 , and t 4 . Use of inhaled corticosteroids and β 2 ‐agonists was significantly decreased after 25 months of treatment in both groups ( P <0.03). SLIT patients showed significant improvements in respiratory function at t 4 (% predicted FEV 1 ( P =0.01), VC ( P =0.002), morning ( P =0.01) and evening ( P =0.03) PEFR), and reduction in daytime asthma score ( P =0.02). In the SLIT group, the post‐treatment PD 20 was 1.75 times higher than the baseline value. There was no change in PD 20 in the placebo group. Compared to the placebo group, the SLIT group showed a significant increase in specific IgE DP ( P =0.05), IgE DF ( P =0.02), IgG4 DP ( P =0.001), and IgG4 DF ( P =0.001) levels after SLIT. QoL scores were similar in both groups at t 0 and t 2 . At t 4 , all scores were better in the SLIT group than in the placebo group, with the differences being most marked for the general perception of health ( P =0.01) and physical pain ( P =0.02). Adverse events were similar in the two groups. This study shows that SLIT in house‐dust‐mite‐related asthma has a good safety profile and improves respiratory function, bronchial hyperreactivity, and QoL." @default.
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• W2051493108 date "1999-03-01" @default.
• W2051493108 modified "2023-10-18" @default.
• W2051493108 title "Sublingual‐swallow immunotherapy (SLIT) in patients with asthma due to house‐dust mites: a double‐blind, placebo‐controlled study" @default.
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• W2051493108 doi "https://doi.org/10.1034/j.1398-9995.1999.00916.x" @default.
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