Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051504306> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2051504306 endingPage "715" @default.
- W2051504306 startingPage "708" @default.
- W2051504306 abstract "Primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, a provisional entity in the 2005 WHO-EORTC classification for cutaneous lymphomas, is not well characterized. Fifteen cases meeting the definition of this entity were identified. Fourteen represented solitary lesions on the head/neck (n=9), upper extremity (n=4), or trunk (n=1). One patient presented with multiple lesions on the trunk and extremities. Histologically, the infiltrate showed a nodular pattern in the dermis and subcutis without epidermotropism, and had a polymorphous composition with a predominance of small to medium-sized CD4-positive T cells. Most cases showed normal T-cell antigen expression; diminished/absent expression of CD7 was seen in three cases and CD2 expression was absent in one case. All cases showed a notable reactive infiltrate including frequent B cells, plasma cells, and histiocytes. Clonal TCR gene rearrangements were detected in each case. No clonal Ig gene rearrangements were detected. Out of the 11 patients with follow-up, none showed systemic disease. The majority resolved without relapse, one without treatment, four with excision, and four with radiation therapy. One patient developed local recurrence. The patient with multiple lesions had disease progression despite chemotherapy and stem cell transplant. These cases highlight the polymorphous histology and prominent reactive B-cell component of this entity. Diagnosis requires molecular genetic analysis, as prominent cytologic atypia and immunophenotypic aberrancy are rare. The differential diagnosis includes reactive lymphoid hyperplasia, mycosis fungoides and cutaneous B-cell lymphomas. In patients with isolated cutaneous lesions, the indolent behavior of this rare T-cell neoplasm should be recognized to avoid unnecessary treatment." @default.
- W2051504306 created "2016-06-24" @default.
- W2051504306 creator A5005471384 @default.
- W2051504306 creator A5010735971 @default.
- W2051504306 creator A5024505450 @default.
- W2051504306 creator A5026248947 @default.
- W2051504306 creator A5055938751 @default.
- W2051504306 date "2008-06-01" @default.
- W2051504306 modified "2023-10-18" @default.
- W2051504306 title "Primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma: a clonal T-cell lymphoproliferative disorder with indolent behavior" @default.
- W2051504306 cites W1989588512 @default.
- W2051504306 cites W2000951230 @default.
- W2051504306 cites W2027140059 @default.
- W2051504306 cites W2030840735 @default.
- W2051504306 cites W2034443587 @default.
- W2051504306 cites W2074510038 @default.
- W2051504306 cites W2090551575 @default.
- W2051504306 cites W2096160655 @default.
- W2051504306 cites W2109371972 @default.
- W2051504306 cites W2129214379 @default.
- W2051504306 cites W2153759047 @default.
- W2051504306 doi "https://doi.org/10.1038/modpathol.2008.40" @default.
- W2051504306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18311111" @default.
- W2051504306 hasPublicationYear "2008" @default.
- W2051504306 type Work @default.
- W2051504306 sameAs 2051504306 @default.
- W2051504306 citedByCount "140" @default.
- W2051504306 countsByYear W20515043062012 @default.
- W2051504306 countsByYear W20515043062013 @default.
- W2051504306 countsByYear W20515043062014 @default.
- W2051504306 countsByYear W20515043062015 @default.
- W2051504306 countsByYear W20515043062016 @default.
- W2051504306 countsByYear W20515043062017 @default.
- W2051504306 countsByYear W20515043062018 @default.
- W2051504306 countsByYear W20515043062019 @default.
- W2051504306 countsByYear W20515043062020 @default.
- W2051504306 countsByYear W20515043062021 @default.
- W2051504306 countsByYear W20515043062022 @default.
- W2051504306 countsByYear W20515043062023 @default.
- W2051504306 crossrefType "journal-article" @default.
- W2051504306 hasAuthorship W2051504306A5005471384 @default.
- W2051504306 hasAuthorship W2051504306A5010735971 @default.
- W2051504306 hasAuthorship W2051504306A5024505450 @default.
- W2051504306 hasAuthorship W2051504306A5026248947 @default.
- W2051504306 hasAuthorship W2051504306A5055938751 @default.
- W2051504306 hasBestOaLocation W20515043061 @default.
- W2051504306 hasConcept C104317684 @default.
- W2051504306 hasConcept C142724271 @default.
- W2051504306 hasConcept C2776995267 @default.
- W2051504306 hasConcept C2777756187 @default.
- W2051504306 hasConcept C2779338263 @default.
- W2051504306 hasConcept C2780117679 @default.
- W2051504306 hasConcept C2780954659 @default.
- W2051504306 hasConcept C2992511266 @default.
- W2051504306 hasConcept C43100952 @default.
- W2051504306 hasConcept C55493867 @default.
- W2051504306 hasConcept C70905583 @default.
- W2051504306 hasConcept C71924100 @default.
- W2051504306 hasConcept C86803240 @default.
- W2051504306 hasConceptScore W2051504306C104317684 @default.
- W2051504306 hasConceptScore W2051504306C142724271 @default.
- W2051504306 hasConceptScore W2051504306C2776995267 @default.
- W2051504306 hasConceptScore W2051504306C2777756187 @default.
- W2051504306 hasConceptScore W2051504306C2779338263 @default.
- W2051504306 hasConceptScore W2051504306C2780117679 @default.
- W2051504306 hasConceptScore W2051504306C2780954659 @default.
- W2051504306 hasConceptScore W2051504306C2992511266 @default.
- W2051504306 hasConceptScore W2051504306C43100952 @default.
- W2051504306 hasConceptScore W2051504306C55493867 @default.
- W2051504306 hasConceptScore W2051504306C70905583 @default.
- W2051504306 hasConceptScore W2051504306C71924100 @default.
- W2051504306 hasConceptScore W2051504306C86803240 @default.
- W2051504306 hasIssue "6" @default.
- W2051504306 hasLocation W20515043061 @default.
- W2051504306 hasLocation W20515043062 @default.
- W2051504306 hasOpenAccess W2051504306 @default.
- W2051504306 hasPrimaryLocation W20515043061 @default.
- W2051504306 hasRelatedWork W1998233932 @default.
- W2051504306 hasRelatedWork W1999717629 @default.
- W2051504306 hasRelatedWork W2027689837 @default.
- W2051504306 hasRelatedWork W2033692034 @default.
- W2051504306 hasRelatedWork W2051504306 @default.
- W2051504306 hasRelatedWork W2099234472 @default.
- W2051504306 hasRelatedWork W2398593007 @default.
- W2051504306 hasRelatedWork W2613473615 @default.
- W2051504306 hasRelatedWork W2928494203 @default.
- W2051504306 hasRelatedWork W3170541899 @default.
- W2051504306 hasVolume "21" @default.
- W2051504306 isParatext "false" @default.
- W2051504306 isRetracted "false" @default.
- W2051504306 magId "2051504306" @default.
- W2051504306 workType "article" @default.