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• W2051504976 abstract "The Saccharomyces cerevisiae kinase-encoding gene (PYK1) has been transformed back into yeast using a derivative of the multicopy vector, pJDB207. High levels of PYK1 expression in these transformants are limited by at least two separate mechanisms. Pyruvate kinase assays and polysome analyses demonstrate that the translation of the PYK1 mRNA is inhibited as its abundance increases. The abundance of the PYK1 mRNA per gene copy also decreases as the copy number of the PYKI gene increases. This is the first report which demonstrates that a eukaryotic glycolytic gene is subject to dosage limitation at the translational level." @default.
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• W2051504976 date "1990-04-01" @default.
• W2051504976 modified "2023-09-23" @default.
• W2051504976 title "Expression of a yeast glycolytic gene is subject to dosage limitation" @default.
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• W2051504976 doi "https://doi.org/10.1016/0378-1119(90)90209-a" @default.
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