Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051509910> ?p ?o ?g. }
- W2051509910 endingPage "75" @default.
- W2051509910 startingPage "69" @default.
- W2051509910 abstract "Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are autoimmune diseases characterized by the immune-mediated demyelination and neurodegeneration of the CNS. Our previous studies showed that Rho kinase inhibitor Fasudil can delay onset, and ameliorate severity of EAE, accompanied by the improvement in myelination and the inhibition of inflammatory responses in the CNS. In this study, we found that Fasudil inhibited the migration of T cells indirectly by affecting the production of inflammatory factors and the expression of chemokines in astrocytes functions, indicating that Fasudil treatment reduced inflammatory cytokines such as TNF-α and IL-6, reactive oxygen species (NO) and chemokines like MIP-3α (CCL-20), RANTES (CCL5), MIP-1α (CCL-3) and MCP-1 (CCL2) in vitro, and blocked the chemotaxis of reactive mononuclear cells in EAE mice. Further studies found that Fasudil treatment reduced the infiltration and accumulation of pathogenic T cells into the CNS. Astrocytes expressing GFAP and CCL-20 were inhibited in Fasudil-treated EAE compared with control mice. These results demonstrate that Fasudil alleviates the pathogenesis of EAE possibly by blocking astrocyte-derived chemokine-mediated migration of inflammatory macrophages and pathogenic T cells, and might be used to treat MS." @default.
- W2051509910 created "2016-06-24" @default.
- W2051509910 creator A5019856455 @default.
- W2051509910 creator A5045137608 @default.
- W2051509910 creator A5051850521 @default.
- W2051509910 creator A5053018220 @default.
- W2051509910 creator A5061893980 @default.
- W2051509910 creator A5070235745 @default.
- W2051509910 creator A5071367202 @default.
- W2051509910 creator A5074650820 @default.
- W2051509910 creator A5081844561 @default.
- W2051509910 creator A5081975222 @default.
- W2051509910 creator A5089462504 @default.
- W2051509910 date "2014-08-01" @default.
- W2051509910 modified "2023-10-13" @default.
- W2051509910 title "The inhibition of Rho kinase blocks cell migration and accumulation possibly by challenging inflammatory cytokines and chemokines on astrocytes" @default.
- W2051509910 cites W1608557519 @default.
- W2051509910 cites W1966161025 @default.
- W2051509910 cites W1968099474 @default.
- W2051509910 cites W1970378131 @default.
- W2051509910 cites W1974448277 @default.
- W2051509910 cites W1975146958 @default.
- W2051509910 cites W1979993194 @default.
- W2051509910 cites W1985148520 @default.
- W2051509910 cites W2001267675 @default.
- W2051509910 cites W2005626830 @default.
- W2051509910 cites W2005799830 @default.
- W2051509910 cites W2012463138 @default.
- W2051509910 cites W2022412338 @default.
- W2051509910 cites W2030133200 @default.
- W2051509910 cites W2030593831 @default.
- W2051509910 cites W2035036667 @default.
- W2051509910 cites W2038471736 @default.
- W2051509910 cites W2045151906 @default.
- W2051509910 cites W2051947267 @default.
- W2051509910 cites W2052741633 @default.
- W2051509910 cites W2059442573 @default.
- W2051509910 cites W2074661552 @default.
- W2051509910 cites W2074850485 @default.
- W2051509910 cites W2079169807 @default.
- W2051509910 cites W2084887202 @default.
- W2051509910 cites W2090654656 @default.
- W2051509910 cites W2093781561 @default.
- W2051509910 cites W2118730986 @default.
- W2051509910 cites W2121719064 @default.
- W2051509910 cites W2134326405 @default.
- W2051509910 cites W2136557471 @default.
- W2051509910 cites W2143479333 @default.
- W2051509910 cites W2152223474 @default.
- W2051509910 cites W2158627911 @default.
- W2051509910 cites W2164714170 @default.
- W2051509910 cites W4233133508 @default.
- W2051509910 doi "https://doi.org/10.1016/j.jns.2014.05.034" @default.
- W2051509910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24952673" @default.
- W2051509910 hasPublicationYear "2014" @default.
- W2051509910 type Work @default.
- W2051509910 sameAs 2051509910 @default.
- W2051509910 citedByCount "21" @default.
- W2051509910 countsByYear W20515099102014 @default.
- W2051509910 countsByYear W20515099102015 @default.
- W2051509910 countsByYear W20515099102016 @default.
- W2051509910 countsByYear W20515099102017 @default.
- W2051509910 countsByYear W20515099102018 @default.
- W2051509910 countsByYear W20515099102019 @default.
- W2051509910 countsByYear W20515099102020 @default.
- W2051509910 countsByYear W20515099102021 @default.
- W2051509910 countsByYear W20515099102022 @default.
- W2051509910 countsByYear W20515099102023 @default.
- W2051509910 crossrefType "journal-article" @default.
- W2051509910 hasAuthorship W2051509910A5019856455 @default.
- W2051509910 hasAuthorship W2051509910A5045137608 @default.
- W2051509910 hasAuthorship W2051509910A5051850521 @default.
- W2051509910 hasAuthorship W2051509910A5053018220 @default.
- W2051509910 hasAuthorship W2051509910A5061893980 @default.
- W2051509910 hasAuthorship W2051509910A5070235745 @default.
- W2051509910 hasAuthorship W2051509910A5071367202 @default.
- W2051509910 hasAuthorship W2051509910A5074650820 @default.
- W2051509910 hasAuthorship W2051509910A5081844561 @default.
- W2051509910 hasAuthorship W2051509910A5081975222 @default.
- W2051509910 hasAuthorship W2051509910A5089462504 @default.
- W2051509910 hasConcept C101666144 @default.
- W2051509910 hasConcept C110015553 @default.
- W2051509910 hasConcept C116484652 @default.
- W2051509910 hasConcept C13373296 @default.
- W2051509910 hasConcept C169760540 @default.
- W2051509910 hasConcept C17991360 @default.
- W2051509910 hasConcept C185592680 @default.
- W2051509910 hasConcept C201800478 @default.
- W2051509910 hasConcept C203014093 @default.
- W2051509910 hasConcept C2776048814 @default.
- W2051509910 hasConcept C2776090121 @default.
- W2051509910 hasConcept C2776914184 @default.
- W2051509910 hasConcept C2777542381 @default.
- W2051509910 hasConcept C2777899865 @default.
- W2051509910 hasConcept C2778486448 @default.
- W2051509910 hasConcept C2778609687 @default.
- W2051509910 hasConcept C2779830541 @default.
- W2051509910 hasConcept C2780640218 @default.