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• W2051509934 abstract "Group II introns are self-splicing ribozymes believed to be the ancestors of spliceosomal introns. Many group II introns encode reverse transcriptases that promote both RNA splicing and intron mobility to new genomic sites. Here we used a circular permutation and crosslinking method to establish 16 intramolecular distance relationships within the mobile Lactococcus lactis Ll.LtrB-ΔORF intron. Using these new constraints together with 13 established tertiary interactions and eight published crosslinks, we modeled a complete three-dimensional structure of the intron. We also used the circular permutation strategy to map RNA-protein interaction sites through fluorescence quenching and crosslinking assays. Our model provides a comprehensive structural framework for understanding the function of group II ribozymes, their natural structural variations, and the mechanisms by which the intron-encoded protein promotes RNA splicing and intron mobility. The model also suggests an arrangement of active site elements that may be conserved in the spliceosome." @default.
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• W2051509934 date "2008-05-01" @default.
• W2051509934 modified "2023-10-17" @default.
• W2051509934 title "A Three-Dimensional Model of a Group II Intron RNA and Its Interaction with the Intron-Encoded Reverse Transcriptase" @default.
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• W2051509934 doi "https://doi.org/10.1016/j.molcel.2008.04.001" @default.
• W2051509934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2724966" @default.
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