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- W2051521796 abstract "The genotoxicity of human fetal cell extract (HFCE) and its effect on the frequency of micronucleated polychromatic erythrocytes (PCE-MNF) in mice induced by cyclophosphamide (CP) were studied. Statistically significant differences were not foud between the control group and each group treated with HFCE (0.3, 3, 30 mg/kg bw). CP (200 mg/kg bw) induced a marked increase in MNF (P < 0.01). Administered together with CP, HFCE suppressed the increase of MNF induced by CP. The reduction effect is dependent on the dose of HFCE. At doses of 3 and 30 mg/kg bw HFCE, MNF decreased markedly (P < 0.05 and < 0/01, respectively). It showed that HFCE did not induced micronucleus formation, while it could suppress the micronucleus formation induced by CP in mice. The results suggested that HFCE might be antimutagenic and have potential value in clinical application." @default.
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- W2051521796 date "1994-10-01" @default.
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- W2051521796 title "Suppressing effects of human fetal cell extract on micronuclei induced by cyclophosphamide in mice" @default.
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- W2051521796 doi "https://doi.org/10.1016/0027-5107(94)90014-0" @default.
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