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- W2051523828 abstract "Results: The incidence of radiation induced moist desquamation was 38.9% across 54 patients. Higher values of V105%, V107% and total breast volume were all associated with a significant increase in risk of radiation induced moist desquamation. For V105% >20% (nZ 25), the rate of moist desquamation was 56.0% compared to 24.1% for V105% 5% (n Z 28), the rate of moist desquamation was 57.1% compared to 19.2% for V107% 1200 cm; nZ 21) was an independent predictor of an increase in breast desquamation (p Z .001; RR, 3.1; 95% CI, 1.5 e 6.5). On subset analysis, in women with larger breast size, both the impact of V107% >5% (p Z .004; RR, 3.4) and the impact of V105% >20% (pZ .026; RR, 2.8) was significant. In women with smaller breast size, no significant difference was observed for the impact of V105% (p Z .78; RR, 1.2) or V107% (p Z .28; RR, 2). Conclusions: When treating the whole breast with forward planned IMRT, limiting the volume of breast tissue receiving greater than 105% and 107% of the prescribed dose is associated with a decrease in radiation-induced moist desquamation. Institutional guidelines such as keeping V105% below 20% and V107% below 5% may benefit in ensuring that women are not exposed to an unnecessary risk of acute skin toxicity. The importance is especially evident in the women with larger breasts; intensive efforts should be made to lower the volume of tissue receiving greater than 105% and 107% of the prescribed dose. Author Disclosure: X. Zhao: None. N. Detorie: None. B. Wood: None. P. Sanghvi: None. S. Advani: None. G. Mansy: None." @default.
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- W2051523828 date "2013-10-01" @default.
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- W2051523828 title "Local Recurrence and Survival for the German Centers in the TARGIT-A (TARGeted Intraoperative Radiation Therapy - Alone) Trial" @default.
- W2051523828 doi "https://doi.org/10.1016/j.ijrobp.2013.06.625" @default.
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