FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051549401> ?p ?o ?g. }

• W2051549401 endingPage "2540" @default.
• W2051549401 startingPage "2533" @default.
• W2051549401 abstract "Although several candidate vaccine antigens have been developed for malaria, there is as yet no effective single vaccine available. There is a growing consensus that the ultimate malaria vaccine will be multivalent, requiring the identification of a suitable cocktail of antigens. However, evaluation of the multitude of potential malaria vaccine antigens in suitable combinations is a daunting task. Here we describe the validation of expression library immunization (ELI) as a tool for the discovery of sequences protective against malaria infection. A genomic Plasmodium chabaudi expression library was constructed comprising ten separate pools of 3000 plasmids. Over three vaccine trials using biolistic delivery of pools composed of 616 to 30,000 plasmids we report up to 63% protection of mice from a challenge with P. chabaudi adami DS, a highly virulent strain. Overall, ELI protected 36% of vaccinated mice against virulent challenge compared with only 3.2% survival of control mice. These results demonstrate that ELI is a suitable approach for screening the malaria genome to identify the components of multivalent vaccines." @default.
• W2051549401 created "2016-06-24" @default.
• W2051549401 creator A5038716576 @default.
• W2051549401 creator A5049896032 @default.
• W2051549401 creator A5076798321 @default.
• W2051549401 creator A5091308736 @default.
• W2051549401 date "2000-05-01" @default.
• W2051549401 modified "2023-10-12" @default.
• W2051549401 title "Expression library immunization protects mice against a challenge with virulent rodent malaria" @default.
• W2051549401 cites W1586802362 @default.
• W2051549401 cites W1791948424 @default.
• W2051549401 cites W1899632165 @default.
• W2051549401 cites W1914759134 @default.
• W2051549401 cites W1956342499 @default.
• W2051549401 cites W1963710292 @default.
• W2051549401 cites W1970213967 @default.
• W2051549401 cites W1978153917 @default.
• W2051549401 cites W2003028612 @default.
• W2051549401 cites W2005404999 @default.
• W2051549401 cites W2009685908 @default.
• W2051549401 cites W2031598154 @default.
• W2051549401 cites W2057530934 @default.
• W2051549401 cites W2060833452 @default.
• W2051549401 cites W2065340937 @default.
• W2051549401 cites W2065849927 @default.
• W2051549401 cites W2069498130 @default.
• W2051549401 cites W2080455926 @default.
• W2051549401 cites W2088663340 @default.
• W2051549401 cites W2089008531 @default.
• W2051549401 cites W2094056350 @default.
• W2051549401 cites W2103728000 @default.
• W2051549401 cites W2118887119 @default.
• W2051549401 cites W2120997299 @default.
• W2051549401 cites W2134097991 @default.
• W2051549401 cites W2141792732 @default.
• W2051549401 cites W2160006268 @default.
• W2051549401 cites W2160232002 @default.
• W2051549401 cites W2185434840 @default.
• W2051549401 cites W2412745608 @default.
• W2051549401 cites W2417555544 @default.
• W2051549401 cites W2572149375 @default.
• W2051549401 doi "https://doi.org/10.1016/s0264-410x(00)00018-9" @default.
• W2051549401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10775787" @default.
• W2051549401 hasPublicationYear "2000" @default.
• W2051549401 type Work @default.
• W2051549401 sameAs 2051549401 @default.
• W2051549401 citedByCount "31" @default.
• W2051549401 countsByYear W20515494012012 @default.
• W2051549401 countsByYear W20515494012018 @default.
• W2051549401 countsByYear W20515494012021 @default.
• W2051549401 crossrefType "journal-article" @default.
• W2051549401 hasAuthorship W2051549401A5038716576 @default.
• W2051549401 hasAuthorship W2051549401A5049896032 @default.
• W2051549401 hasAuthorship W2051549401A5076798321 @default.
• W2051549401 hasAuthorship W2051549401A5091308736 @default.
• W2051549401 hasConcept C104317684 @default.
• W2051549401 hasConcept C141231307 @default.
• W2051549401 hasConcept C147483822 @default.
• W2051549401 hasConcept C159047783 @default.
• W2051549401 hasConcept C203014093 @default.
• W2051549401 hasConcept C22744801 @default.
• W2051549401 hasConcept C2775867548 @default.
• W2051549401 hasConcept C2778048844 @default.
• W2051549401 hasConcept C2778371730 @default.
• W2051549401 hasConcept C2780789526 @default.
• W2051549401 hasConcept C2780801004 @default.
• W2051549401 hasConcept C2781034427 @default.
• W2051549401 hasConcept C40767141 @default.
• W2051549401 hasConcept C54355233 @default.
• W2051549401 hasConcept C60987743 @default.
• W2051549401 hasConcept C86803240 @default.
• W2051549401 hasConcept C92087593 @default.
• W2051549401 hasConceptScore W2051549401C104317684 @default.
• W2051549401 hasConceptScore W2051549401C141231307 @default.
• W2051549401 hasConceptScore W2051549401C147483822 @default.
• W2051549401 hasConceptScore W2051549401C159047783 @default.
• W2051549401 hasConceptScore W2051549401C203014093 @default.
• W2051549401 hasConceptScore W2051549401C22744801 @default.
• W2051549401 hasConceptScore W2051549401C2775867548 @default.
• W2051549401 hasConceptScore W2051549401C2778048844 @default.
• W2051549401 hasConceptScore W2051549401C2778371730 @default.
• W2051549401 hasConceptScore W2051549401C2780789526 @default.
• W2051549401 hasConceptScore W2051549401C2780801004 @default.
• W2051549401 hasConceptScore W2051549401C2781034427 @default.
• W2051549401 hasConceptScore W2051549401C40767141 @default.
• W2051549401 hasConceptScore W2051549401C54355233 @default.
• W2051549401 hasConceptScore W2051549401C60987743 @default.
• W2051549401 hasConceptScore W2051549401C86803240 @default.
• W2051549401 hasConceptScore W2051549401C92087593 @default.
• W2051549401 hasIssue "23" @default.
• W2051549401 hasLocation W20515494011 @default.
• W2051549401 hasLocation W20515494012 @default.
• W2051549401 hasOpenAccess W2051549401 @default.
• W2051549401 hasPrimaryLocation W20515494011 @default.
• W2051549401 hasRelatedWork W1966221413 @default.
• W2051549401 hasRelatedWork W2015243764 @default.
• W2051549401 hasRelatedWork W2040901127 @default.
• W2051549401 hasRelatedWork W2053124485 @default.

• next