Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051550720> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2051550720 endingPage "1381" @default.
- W2051550720 startingPage "1373" @default.
- W2051550720 abstract "Thiamin-pyrophosphate is an essential cofactor in all living systems. The biosynthesis of both the thiazole and the pyrimidine moieties of this cofactor involves new biosynthetic chemistry. Thiazole-phosphate synthase (ThiG) catalyses the formation of the thiazole moiety of thiamin-pyrophosphate from 1-deoxy-D-xylulose-5-phosphate (DXP), dehydroglycine and the sulfur carrier protein (ThiS), modified on its carboxy terminus as a thiocarboxylate (ThiS-thiocarboxylate). Thiazole biosynthesis is initiated by the formation of a ThiG/DXP imine, which then tautomerizes to an amino-ketone. In this paper we study the sulfur transfer from ThiS-thiocarboxylate to this amino-ketone and trap a new thioenolate intermediate. Surprisingly, thiazole formation results in the replacement of the ThiS-thiocarboxylate sulfur with an oxygen from DXP and not from the buffer, as shown by electrospray ionization Fourier transform mass spectrometry (ESI-FTMS) using (18)O labeling of the 13C-, 15N-depleted protein. These observations further clarify the mechanism of the complex thiazole biosynthesis in bacteria." @default.
- W2051550720 created "2016-06-24" @default.
- W2051550720 creator A5000650060 @default.
- W2051550720 creator A5028893802 @default.
- W2051550720 creator A5064237607 @default.
- W2051550720 creator A5082720301 @default.
- W2051550720 date "2004-10-01" @default.
- W2051550720 modified "2023-10-10" @default.
- W2051550720 title "The Biosynthesis of the Thiazole Phosphate Moiety of Thiamin" @default.
- W2051550720 cites W1519955500 @default.
- W2051550720 cites W1578299567 @default.
- W2051550720 cites W1964819391 @default.
- W2051550720 cites W1978663690 @default.
- W2051550720 cites W2025538655 @default.
- W2051550720 cites W2034174616 @default.
- W2051550720 cites W2034530880 @default.
- W2051550720 cites W2041551197 @default.
- W2051550720 cites W2045964491 @default.
- W2051550720 cites W2062636923 @default.
- W2051550720 cites W2066558357 @default.
- W2051550720 cites W2083013894 @default.
- W2051550720 cites W2083991421 @default.
- W2051550720 cites W2085145164 @default.
- W2051550720 cites W2135810623 @default.
- W2051550720 cites W2136699027 @default.
- W2051550720 cites W2138648425 @default.
- W2051550720 doi "https://doi.org/10.1016/j.chembiol.2004.08.009" @default.
- W2051550720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15489164" @default.
- W2051550720 hasPublicationYear "2004" @default.
- W2051550720 type Work @default.
- W2051550720 sameAs 2051550720 @default.
- W2051550720 citedByCount "24" @default.
- W2051550720 countsByYear W20515507202015 @default.
- W2051550720 countsByYear W20515507202016 @default.
- W2051550720 countsByYear W20515507202017 @default.
- W2051550720 countsByYear W20515507202019 @default.
- W2051550720 countsByYear W20515507202020 @default.
- W2051550720 countsByYear W20515507202021 @default.
- W2051550720 countsByYear W20515507202022 @default.
- W2051550720 countsByYear W20515507202023 @default.
- W2051550720 crossrefType "journal-article" @default.
- W2051550720 hasAuthorship W2051550720A5000650060 @default.
- W2051550720 hasAuthorship W2051550720A5028893802 @default.
- W2051550720 hasAuthorship W2051550720A5064237607 @default.
- W2051550720 hasAuthorship W2051550720A5082720301 @default.
- W2051550720 hasBestOaLocation W20515507201 @default.
- W2051550720 hasConcept C162356407 @default.
- W2051550720 hasConcept C181199279 @default.
- W2051550720 hasConcept C185592680 @default.
- W2051550720 hasConcept C197957613 @default.
- W2051550720 hasConcept C2776043855 @default.
- W2051550720 hasConcept C2776568683 @default.
- W2051550720 hasConcept C2778464347 @default.
- W2051550720 hasConcept C2780047943 @default.
- W2051550720 hasConcept C40684141 @default.
- W2051550720 hasConcept C43617362 @default.
- W2051550720 hasConcept C553450214 @default.
- W2051550720 hasConcept C55493867 @default.
- W2051550720 hasConcept C71240020 @default.
- W2051550720 hasConceptScore W2051550720C162356407 @default.
- W2051550720 hasConceptScore W2051550720C181199279 @default.
- W2051550720 hasConceptScore W2051550720C185592680 @default.
- W2051550720 hasConceptScore W2051550720C197957613 @default.
- W2051550720 hasConceptScore W2051550720C2776043855 @default.
- W2051550720 hasConceptScore W2051550720C2776568683 @default.
- W2051550720 hasConceptScore W2051550720C2778464347 @default.
- W2051550720 hasConceptScore W2051550720C2780047943 @default.
- W2051550720 hasConceptScore W2051550720C40684141 @default.
- W2051550720 hasConceptScore W2051550720C43617362 @default.
- W2051550720 hasConceptScore W2051550720C553450214 @default.
- W2051550720 hasConceptScore W2051550720C55493867 @default.
- W2051550720 hasConceptScore W2051550720C71240020 @default.
- W2051550720 hasIssue "10" @default.
- W2051550720 hasLocation W20515507201 @default.
- W2051550720 hasLocation W20515507202 @default.
- W2051550720 hasOpenAccess W2051550720 @default.
- W2051550720 hasPrimaryLocation W20515507201 @default.
- W2051550720 hasRelatedWork W1525214985 @default.
- W2051550720 hasRelatedWork W1964819391 @default.
- W2051550720 hasRelatedWork W2001867962 @default.
- W2051550720 hasRelatedWork W2003523341 @default.
- W2051550720 hasRelatedWork W2042347070 @default.
- W2051550720 hasRelatedWork W2080899182 @default.
- W2051550720 hasRelatedWork W2084997161 @default.
- W2051550720 hasRelatedWork W2135810623 @default.
- W2051550720 hasRelatedWork W2208020336 @default.
- W2051550720 hasRelatedWork W3020870132 @default.
- W2051550720 hasVolume "11" @default.
- W2051550720 isParatext "false" @default.
- W2051550720 isRetracted "false" @default.
- W2051550720 magId "2051550720" @default.
- W2051550720 workType "article" @default.