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- W2051551497 abstract "Objective: To compare two methods of determining a therapeutic range of activated partial thromboplastin time (aPT) results. Design: Cohort studies. Setting: Referral teaching hospital. Patients: Inpatients who received unfractionated heparin intravenously for venous thromboembolic disease. Measurements: A therapeutic range determined by aPT ratios of 1.5 to 2.5 times the control value as compared with a therapeutic range determined by protamine titration heparin levels of 0.2 to 0.4 U/mL. Results: For all aPT reagents studied, a ratio of 1.5 times the control value is much less than a minimum protamine titration heparin level of 0.2 U/mL. Various manufacturers' aPT reagents and reagent lots from the same manufacturer show considerable variation in response to heparin and therefore have different therapeutic ranges. Conclusions: A different dose of heparin would be required to produce an aPT ratio of 1.5 times the control value, depending on the reagent used. Establishing a therapeutic range for aPT results using protamine titration heparin levels of 0.2 to 0.4 U/mL as a reference standard is practical and compensates for the variable response of aPT reagents to heparin." @default.
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- W2051551497 date "1993-07-15" @default.
- W2051551497 modified "2023-09-25" @default.
- W2051551497 title "Establishing a Therapeutic Range for Heparin Therapy" @default.
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- W2051551497 doi "https://doi.org/10.7326/0003-4819-119-2-199307150-00002" @default.
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