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• W2051551743 abstract "The potential neuroprotective effects of the GABA(A) receptor agonists THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) and muscimol, and the selective GluR5 kainate receptor agonist ATPA ((RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid), which activates GABAergic interneurons, were examined in hippocampal slice cultures exposed to N-methyl-D-aspartate (NMDA). The NMDA-induced excitotoxicity was quantified by densitometric measurements of propidium iodide (PI) uptake. THIP (100-1000 microM) was neuroprotective in slice cultures co-exposed to NMDA (10 microM) for 48 h, while muscimol (100-1000 microM) and ATPA (1-3 microM) were without effect. The results demonstrate that direct GABA(A) agonism can mediate neuroprotection in the hippocampus in vitro as previously suggested in vivo." @default.
• W2051551743 created "2016-06-24" @default.
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• W2051551743 date "2003-05-01" @default.
• W2051551743 modified "2023-09-26" @default.
• W2051551743 title "The GABAA receptor agonist THIP is neuroprotective in organotypic hippocampal slice cultures" @default.
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• W2051551743 doi "https://doi.org/10.1016/s0006-8993(03)02550-2" @default.
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