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- W2051551965 abstract "In view of the wide ranging functions of cyclic AMP as a second messenger, including osmoregulation, we have studied the acute and chronic effects of rolipram on plasma and urinary osmolality. Ten healthy male volunteers aged between 20 and 40 years were studied prior to, after 24 h and after 1 week of rolipram given orally at a dosage of 1 mg three times daily. Simultaneous blood and urine samples were taken at 09.00 h on each occasion after an overnight fast. Osmolality was measured by freezing point depression" @default.
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- W2051551965 date "1990-03-01" @default.
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- W2051551965 title "The acute toxic effect of the phosphodiesterase inhibitor rolipram on plasma osmolality [letter]" @default.
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- W2051551965 doi "https://doi.org/10.1111/j.1365-2125.1990.tb03651.x" @default.
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