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• W2051554967 abstract "In the present study, rats self-administered sucrose 6 h/day for 10 days. Separate groups of rats were then tested on day 1 or day 30 of forced abstinence. After they had responded to near extinction, rats were injected with either saline or cocaine (2.5, 5, 10, or 20 mg/kg intraperitoneal) and then allowed to respond to a sucrose-paired stimulus. Locomotor activity was assessed during testing. Rats pressed more during the extinction responding phase of testing on day 30 than on day 1 of forced abstinence, and this incubation of craving was accompanied by a time-dependent increase in locomotor activity. Compared with saline, cocaine increased responding for the sucrose-paired cue on day 1 of forced abstinence at the 5 mg/kg dose only. In contrast, responding on day 30 was increased at the 10 and 20 mg/kg doses. Locomotor activity increased dose-dependently at both forced-abstinence time points, suggesting a dissociation between cocaine-induced locomotion and cocaine-elevated responding for a sucrose-paired stimulus. These results also indicate that there are time-dependent changes in how cocaine affects sucrose craving." @default.
• W2051554967 created "2016-06-24" @default.
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• W2051554967 date "2006-03-01" @default.
• W2051554967 modified "2023-10-17" @default.
• W2051554967 title "Time-dependent dissociation of cocaine dose–response effects on sucrose craving and locomotion" @default.
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• W2051554967 doi "https://doi.org/10.1097/01.fbp.0000190686.23103.f8" @default.
• W2051554967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2881829" @default.
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