FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051566911> ?p ?o ?g. }

• W2051566911 endingPage "1277" @default.
• W2051566911 startingPage "1267" @default.
• W2051566911 abstract "Communication-deficient cells (the SKHep1 cell line) were stably transfected with a plasmid containing cDNA which encodes the major gap junction protein of rat liver, connexin32. Application of the dual whole-cell voltage clamp technique with patch electrodes to pairs of transfected SKHep1 cells revealed strong sensitivity of junctional conductance (gj) to transjunctional voltages (Vjs) of either polarity, with the ratio of minimal to maximal gj (gmin/gmax) being approximately 0.1 at the highest Vjs. Steady-state gj values as a function of voltages of either polarity were well fit by the Boltzmann equation. V0, the voltage at which gj was reduced by 50%, was approximately 25-30 mV; A, the Boltzmann parameter describing voltage dependence, was approximately 0.06 (corresponding to an energy difference between states of approximately 1 kCal/mol and to approximately 2 gating charges moving through the field). The kinetics of the transjunctional voltage dependence were slow (tau greater than 5 s at 20-40 mV, tau = 2 s at and beyond 70 mV). Voltage sensitivity of the opening rate constant (alpha) was approximately 30% lower than that of the closing rate constant (beta) over the Vj range 0-70 mV; at higher voltages, voltage sensitivity of alpha and beta saturated. The kinetic response of gj to a paradigm in which gj was first rendered low by a prepulse of opposite polarity indicated that the voltage sensors are likely to be arranged in series. Transitions between open and closed states in response to transjunctional voltages of either polarity are single order processes; transitions from one closed state to the other involve passage through the open state." @default.
• W2051566911 created "2016-06-24" @default.
• W2051566911 creator A5014193358 @default.
• W2051566911 creator A5063123386 @default.
• W2051566911 creator A5066760140 @default.
• W2051566911 date "1991-11-01" @default.
• W2051566911 modified "2023-10-18" @default.
• W2051566911 title "Connexin32 gap junction channels in stably transfected cells. Equilibrium and kinetic properties" @default.
• W2051566911 cites W1580364233 @default.
• W2051566911 cites W1981321532 @default.
• W2051566911 cites W1982254394 @default.
• W2051566911 cites W1985940938 @default.
• W2051566911 cites W1988316236 @default.
• W2051566911 cites W1994553626 @default.
• W2051566911 cites W2004205861 @default.
• W2051566911 cites W2006192148 @default.
• W2051566911 cites W2006905166 @default.
• W2051566911 cites W2019374116 @default.
• W2051566911 cites W2026919278 @default.
• W2051566911 cites W2033640173 @default.
• W2051566911 cites W2051710352 @default.
• W2051566911 cites W2052093835 @default.
• W2051566911 cites W2055762046 @default.
• W2051566911 cites W2067822038 @default.
• W2051566911 cites W2076700981 @default.
• W2051566911 cites W2085684041 @default.
• W2051566911 cites W2086243893 @default.
• W2051566911 cites W2094746218 @default.
• W2051566911 cites W2102155514 @default.
• W2051566911 cites W2132478632 @default.
• W2051566911 cites W2137932282 @default.
• W2051566911 cites W2147681062 @default.
• W2051566911 cites W2163922128 @default.
• W2051566911 cites W2175134346 @default.
• W2051566911 cites W2256783719 @default.
• W2051566911 cites W2398116510 @default.
• W2051566911 cites W2409473628 @default.
• W2051566911 cites W2436082995 @default.
• W2051566911 doi "https://doi.org/10.1016/s0006-3495(91)82160-9" @default.
• W2051566911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1260180" @default.
• W2051566911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1722120" @default.
• W2051566911 hasPublicationYear "1991" @default.
• W2051566911 type Work @default.
• W2051566911 sameAs 2051566911 @default.
• W2051566911 citedByCount "44" @default.
• W2051566911 countsByYear W20515669112012 @default.
• W2051566911 countsByYear W20515669112014 @default.
• W2051566911 crossrefType "journal-article" @default.
• W2051566911 hasAuthorship W2051566911A5014193358 @default.
• W2051566911 hasAuthorship W2051566911A5063123386 @default.
• W2051566911 hasAuthorship W2051566911A5066760140 @default.
• W2051566911 hasBestOaLocation W20515669111 @default.
• W2051566911 hasConcept C119599485 @default.
• W2051566911 hasConcept C121332964 @default.
• W2051566911 hasConcept C121932024 @default.
• W2051566911 hasConcept C12554922 @default.
• W2051566911 hasConcept C127413603 @default.
• W2051566911 hasConcept C1491633281 @default.
• W2051566911 hasConcept C158157758 @default.
• W2051566911 hasConcept C165801399 @default.
• W2051566911 hasConcept C185592680 @default.
• W2051566911 hasConcept C194544171 @default.
• W2051566911 hasConcept C26873012 @default.
• W2051566911 hasConcept C2777361361 @default.
• W2051566911 hasConcept C55493867 @default.
• W2051566911 hasConcept C62520636 @default.
• W2051566911 hasConcept C79879829 @default.
• W2051566911 hasConcept C81370116 @default.
• W2051566911 hasConcept C86803240 @default.
• W2051566911 hasConceptScore W2051566911C119599485 @default.
• W2051566911 hasConceptScore W2051566911C121332964 @default.
• W2051566911 hasConceptScore W2051566911C121932024 @default.
• W2051566911 hasConceptScore W2051566911C12554922 @default.
• W2051566911 hasConceptScore W2051566911C127413603 @default.
• W2051566911 hasConceptScore W2051566911C1491633281 @default.
• W2051566911 hasConceptScore W2051566911C158157758 @default.
• W2051566911 hasConceptScore W2051566911C165801399 @default.
• W2051566911 hasConceptScore W2051566911C185592680 @default.
• W2051566911 hasConceptScore W2051566911C194544171 @default.
• W2051566911 hasConceptScore W2051566911C26873012 @default.
• W2051566911 hasConceptScore W2051566911C2777361361 @default.
• W2051566911 hasConceptScore W2051566911C55493867 @default.
• W2051566911 hasConceptScore W2051566911C62520636 @default.
• W2051566911 hasConceptScore W2051566911C79879829 @default.
• W2051566911 hasConceptScore W2051566911C81370116 @default.
• W2051566911 hasConceptScore W2051566911C86803240 @default.
• W2051566911 hasIssue "5" @default.
• W2051566911 hasLocation W20515669111 @default.
• W2051566911 hasLocation W20515669112 @default.
• W2051566911 hasLocation W20515669113 @default.
• W2051566911 hasLocation W20515669114 @default.
• W2051566911 hasOpenAccess W2051566911 @default.
• W2051566911 hasPrimaryLocation W20515669111 @default.
• W2051566911 hasRelatedWork W1964390462 @default.
• W2051566911 hasRelatedWork W2021240079 @default.
• W2051566911 hasRelatedWork W2041893868 @default.
• W2051566911 hasRelatedWork W2057358463 @default.
• W2051566911 hasRelatedWork W2092506292 @default.

• next