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• W2051567289 endingPage "104" @default.
• W2051567289 startingPage "96" @default.
• W2051567289 abstract "The median raphe nucleus (MR) exerts a pronounced desynchronizing influence on the hippocampal EEG. MR stimulation disrupts theta, while MR lesions produce constant uninterrupted theta. The MR receives pronounced excitatory amino acid (EAA)-containing afferents that have been implicated in several MR-mediated behaviors. The present study examined the effects on the hippocampal EEG of MR injections of the following EAA antagonists in the urethane-anesthetized rat: 2-amino-7-phosphonoheptanoate (AP-7), dizocilpine maleate (MK-801), and γ-glutamyl-aminomethylsulfonic acid (GAMS). MR injections of the competitive (AP-7) and non-competitive (MK-801) N-methyl-d-aspartic acid (NMDA) receptor antagonists produced theta at short latencies (2.86 min; 4.02 min, respectively) and for long durations (116.1 min; 66.8 min, respectively). It was further shown that the theta-eliciting effects of AP-7 injections could be reliably and temporarily reversed with MR injections of NMDA. MR injections of the kainate/quisqualate receptor antagonist (GAMS) also produced theta at relatively short latencies (6.5 min) and for long durations (60.5 min) indicating that EAA effects on the MR are not NMDA receptor specific. Injections of each of the foregoing EAA antagonists into regions of the brainstem adjacent to the MR including the dorsal raphe nucleus and the medullary or pontine reticular formation generated theta at very long latencies or were without effect. The present findings indicate EAA afferents to the MR normally exert an excitatory influence on the MR in its desynchronization of the hippocampal EEG, whereas the removal of EAA inputs to MR produces the opposite; a reduction of MR activity and hence the elicitation of theta. Thus, EAA afferents to the MR appear to play an important modulary role in the MR control of the hippocampal EGG." @default.
• W2051567289 created "2016-06-24" @default.
• W2051567289 creator A5005430405 @default.
• W2051567289 creator A5063444335 @default.
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• W2051567289 date "1994-08-01" @default.
• W2051567289 modified "2023-09-23" @default.
• W2051567289 title "Injections of excitatory amino acid antagonists into the median raphe nucleus produce hippocampal theta rhythm in the urethane-anesthetized rat" @default.
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• W2051567289 doi "https://doi.org/10.1016/0006-8993(94)91575-x" @default.
• W2051567289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7982102" @default.
• W2051567289 hasPublicationYear "1994" @default.
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