FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051567318> ?p ?o ?g. }

• W2051567318 endingPage "2963" @default.
• W2051567318 startingPage "2951" @default.
• W2051567318 abstract "ABSTRACT When Shiga toxin-producing Escherichia coli (STEC) strains emerged as agents of human disease, two types of toxin were identified: Shiga toxin type 1 (Stx1) (almost identical to Shiga toxin produced by Shigella dysenteriae type 1) and the immunologically distinct type 2 (Stx2). Subsequently, numerous STEC strains have been characterized that express toxins with variations in amino acid sequence, some of which confer unique biological properties. These variants were grouped within the Stx1 or Stx2 type and often assigned names to indicate that they were not identical in sequence or phenotype to the main Stx1 or Stx2 type. A lack of specificity or consistency in toxin nomenclature has led to much confusion in the characterization of STEC strains. Because serious outcomes of infection have been attributed to certain Stx subtypes and less so with others, we sought to better define the toxin subtypes within the main Stx1 and Stx2 types. We compared the levels of relatedness of 285 valid sequence variants of Stx1 and Stx2 and identified common sequences characteristic of each of three Stx/Stx1 and seven Stx2 subtypes. A novel, simple PCR subtyping method was developed, independently tested on a battery of 48 prototypic STEC strains, and improved at six clinical and research centers to test the reproducibility, sensitivity, and specificity of the PCR. Using a consistent schema for nomenclature of the Stx toxins and stx genes by phylogenetic sequence-based relatedness of the holotoxin proteins, we developed a typing approach that should obviate the need to bioassay each newly described toxin and that predicts important biological characteristics." @default.
• W2051567318 created "2016-06-24" @default.
• W2051567318 creator A5015328482 @default.
• W2051567318 creator A5019181286 @default.
• W2051567318 creator A5024268976 @default.
• W2051567318 creator A5025115465 @default.
• W2051567318 creator A5025272359 @default.
• W2051567318 creator A5031312139 @default.
• W2051567318 creator A5037678266 @default.
• W2051567318 creator A5042458897 @default.
• W2051567318 creator A5045671781 @default.
• W2051567318 creator A5047822871 @default.
• W2051567318 creator A5050189143 @default.
• W2051567318 creator A5066278410 @default.
• W2051567318 creator A5073724334 @default.
• W2051567318 creator A5087521692 @default.
• W2051567318 creator A5090899164 @default.
• W2051567318 date "2012-09-01" @default.
• W2051567318 modified "2023-10-02" @default.
• W2051567318 title "Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx Nomenclature" @default.
• W2051567318 cites W1505020864 @default.
• W2051567318 cites W1749990518 @default.
• W2051567318 cites W1819962733 @default.
• W2051567318 cites W1920500439 @default.
• W2051567318 cites W1947835833 @default.
• W2051567318 cites W1967582134 @default.
• W2051567318 cites W1982303914 @default.
• W2051567318 cites W1984326040 @default.
• W2051567318 cites W1984583357 @default.
• W2051567318 cites W1992113077 @default.
• W2051567318 cites W1995189731 @default.
• W2051567318 cites W1995665888 @default.
• W2051567318 cites W2002423834 @default.
• W2051567318 cites W2003580215 @default.
• W2051567318 cites W2004888237 @default.
• W2051567318 cites W2007253849 @default.
• W2051567318 cites W2012895049 @default.
• W2051567318 cites W2013910995 @default.
• W2051567318 cites W2023731533 @default.
• W2051567318 cites W2031797708 @default.
• W2051567318 cites W2032316272 @default.
• W2051567318 cites W2035603461 @default.
• W2051567318 cites W2049390717 @default.
• W2051567318 cites W2052511309 @default.
• W2051567318 cites W2054231911 @default.
• W2051567318 cites W2055002532 @default.
• W2051567318 cites W2070810653 @default.
• W2051567318 cites W2076153835 @default.
• W2051567318 cites W2079179705 @default.
• W2051567318 cites W2081759425 @default.
• W2051567318 cites W2086731593 @default.
• W2051567318 cites W2096176336 @default.
• W2051567318 cites W2098057755 @default.
• W2051567318 cites W2100488834 @default.
• W2051567318 cites W2102411651 @default.
• W2051567318 cites W2105137655 @default.
• W2051567318 cites W2109202458 @default.
• W2051567318 cites W2110285283 @default.
• W2051567318 cites W2110459109 @default.
• W2051567318 cites W2112705397 @default.
• W2051567318 cites W2114418177 @default.
• W2051567318 cites W2118152759 @default.
• W2051567318 cites W2119261996 @default.
• W2051567318 cites W2129679668 @default.
• W2051567318 cites W2130480234 @default.
• W2051567318 cites W2143077693 @default.
• W2051567318 cites W2148775773 @default.
• W2051567318 cites W2152183607 @default.
• W2051567318 cites W2152964535 @default.
• W2051567318 cites W2155607625 @default.
• W2051567318 cites W2157306238 @default.
• W2051567318 cites W2165883557 @default.
• W2051567318 cites W2167612548 @default.
• W2051567318 cites W2169234405 @default.
• W2051567318 cites W2170996280 @default.
• W2051567318 cites W2171174295 @default.
• W2051567318 cites W977140592 @default.
• W2051567318 doi "https://doi.org/10.1128/jcm.00860-12" @default.
• W2051567318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3421821" @default.
• W2051567318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22760050" @default.
• W2051567318 hasPublicationYear "2012" @default.
• W2051567318 type Work @default.
• W2051567318 sameAs 2051567318 @default.
• W2051567318 citedByCount "648" @default.
• W2051567318 countsByYear W20515673182012 @default.
• W2051567318 countsByYear W20515673182013 @default.
• W2051567318 countsByYear W20515673182014 @default.
• W2051567318 countsByYear W20515673182015 @default.
• W2051567318 countsByYear W20515673182016 @default.
• W2051567318 countsByYear W20515673182017 @default.
• W2051567318 countsByYear W20515673182018 @default.
• W2051567318 countsByYear W20515673182019 @default.
• W2051567318 countsByYear W20515673182020 @default.
• W2051567318 countsByYear W20515673182021 @default.
• W2051567318 countsByYear W20515673182022 @default.
• W2051567318 countsByYear W20515673182023 @default.
• W2051567318 crossrefType "journal-article" @default.
• W2051567318 hasAuthorship W2051567318A5015328482 @default.

• next