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• W2051570920 abstract "The actions of noradrenaline (NA) on the neurons acutely isolated from paratracheal ganglia of rats and the ionic mechanisms involved were studied with nystatin-perforated patch recording configuration. Under current-clamp conditions, application of 10 μM NA produced membrane depolarization followed by repetitive action potentials. NA evoked an inward cationic current under voltage-clamp conditions at a holding potential of −60 mV. Transient tail inward (‘hump’) current was also induced by washout of NA. The NA-induced current was reduced by extracellular Ca2+ and Mg2+, with half-maximal concentrations of 0.7 and 2.6 mM for Ca2+ and Mg2+, respectively. Phenylephrine, an α1-adrenoceptor agonist, mimicked the NA-induced current, but the ‘hump’ current did not occur upon washout of phenylephrine. The NA-induced current was inhibited by prazosin and WB-4101, α1-adrenoceptor antagonists. In contrast, in the presence of yohimbine, an α2-adrenoceptor antagonist, the NA-induced current was potentiated and the washout of NA failed to evoke the ‘hump’ current. The pretreatment of paratracheal neurons with pertussis toxin also potentiated the NA-induced current. The NA-induced inward current was inhibited by pretreatment with U73122, a phospholipase C inhibitor, and xestospongin-C, a membrane-permeable IP3 receptor antagonist. On the other hand, thapsigargin, BAPTA-AM and calmidazolium had no effect on the NA-induced current, suggesting that release of Ca2+ from intracellular Ca2+ stores via IP3 receptors is not involved in the NA action. The cationic channels activated by NA play an important physiological role in neuronal membrane depolarization in rat paratracheal ganglia." @default.
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• W2051570920 date "2004-10-01" @default.
• W2051570920 modified "2023-10-03" @default.
• W2051570920 title "Noradrenaline-induced cation currents in isolated rat paratracheal ganglion neurons" @default.
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• W2051570920 doi "https://doi.org/10.1016/j.brainres.2004.07.011" @default.
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