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• W2051572011 abstract "Medical treatment of endometriosis relies on drugs that suppress ovarian steroids and induce an hypoestrogenic state that causes atrophy of ectopic endometrium. Gonadotrophin-releasing hormone (GnRH) analogues, danazol, progestogens and oestrogen-progestin combinations have all proven effective in relieving pain and reducing the extent of endometriotic implants. However, symptoms often recur after discontinuation of therapy and hypoestrogenism-related side effects limit the long-term use of most medications. Furthermore, these therapies are of limited value in patients with a desire to become pregnant because they inhibit ovulation. An important target for current research is to identify effective therapies that can be safely administered in the long term. GnRH analogues with add-back therapy, progestogens and continuous oral contraceptive are options available for a medium or long-term systemic treatment. Mifepristone, an antiprogestogen, may constitute an alternative if encouraging preliminary data on its effectiveness and tolerability are confirmed. A very appealing area of interest is the possibility of treating endometriosis without suppressing ovarian function. Aromatase inhibitors might have such characteristics as they have been shown to inhibit oestrogen production selectively in endometriotic lesions, without affecting ovarian function; the clinical role of these drugs in the treatment of endometriosis is under evaluation. Levonorgestrel medicated intrauterine device has proven effective in relieving dysmenorrhoea associated with endometriosis, as well as pain associated with rectovaginal endometriosis. Although a systemic absorption is present determining side effects, this approach is promising in the long-term management of this condition. A fundamental objective of research in endometriosis treatment is to develop new therapeutic approaches based on the findings from experimental studies on the aetiopathogenesis of the disease; current research is focusing on anti-inflammatory drugs and modulators of the immune system. TNF-binding protein-1 and IL-12 have proved effective in reducing endometriotic lesions in animal models, while pentoxifylline and INF-α2b have shown encouraging results in clinical studies. This area may be of paramount importance in the near future in order to develop a therapy that could prevent or eradicate endometriosis rather than merely relieving the symptoms." @default.
• W2051572011 created "2016-06-24" @default.
• W2051572011 creator A5046289347 @default.
• W2051572011 creator A5087414064 @default.
• W2051572011 date "2004-05-01" @default.
• W2051572011 modified "2023-09-23" @default.
• W2051572011 title "Emerging drugs for endometriosis" @default.
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• W2051572011 cites W164119867 @default.
• W2051572011 cites W173416263 @default.
• W2051572011 cites W1745883223 @default.
• W2051572011 cites W178615457 @default.
• W2051572011 cites W1873019234 @default.
• W2051572011 cites W1901751800 @default.
• W2051572011 cites W1910306760 @default.
• W2051572011 cites W1965928435 @default.
• W2051572011 cites W1973104602 @default.
• W2051572011 cites W1973438143 @default.
• W2051572011 cites W1977489946 @default.
• W2051572011 cites W1978310578 @default.
• W2051572011 cites W1982798184 @default.
• W2051572011 cites W1986883507 @default.
• W2051572011 cites W1999146558 @default.
• W2051572011 cites W2002687754 @default.
• W2051572011 cites W2010345295 @default.
• W2051572011 cites W201040832 @default.
• W2051572011 cites W2014270274 @default.
• W2051572011 cites W2015536508 @default.
• W2051572011 cites W2027541335 @default.
• W2051572011 cites W2032098472 @default.
• W2051572011 cites W2035429304 @default.
• W2051572011 cites W2036646106 @default.
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• W2051572011 cites W2044951881 @default.
• W2051572011 cites W2045757011 @default.
• W2051572011 cites W2047533080 @default.
• W2051572011 cites W2052734866 @default.
• W2051572011 cites W2057603065 @default.
• W2051572011 cites W2059455531 @default.
• W2051572011 cites W2061805178 @default.
• W2051572011 cites W2065313634 @default.
• W2051572011 cites W2068661759 @default.
• W2051572011 cites W2071815514 @default.
• W2051572011 cites W2072581914 @default.
• W2051572011 cites W2077746532 @default.
• W2051572011 cites W2085646442 @default.
• W2051572011 cites W2089856942 @default.
• W2051572011 cites W2090062039 @default.
• W2051572011 cites W2093512443 @default.
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• W2051572011 cites W2105194279 @default.
• W2051572011 cites W2105478806 @default.
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• W2051572011 cites W2123364070 @default.
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• W2051572011 cites W2159093950 @default.
• W2051572011 cites W2159803441 @default.
• W2051572011 cites W2164774649 @default.
• W2051572011 cites W2165232862 @default.
• W2051572011 cites W2166974601 @default.
• W2051572011 cites W2170554336 @default.
• W2051572011 cites W2228635764 @default.
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• W2051572011 doi "https://doi.org/10.1517/14728214.9.1.167" @default.
• W2051572011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15155142" @default.
• W2051572011 hasPublicationYear "2004" @default.
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