FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051572188> ?p ?o ?g. }

• W2051572188 endingPage "203" @default.
• W2051572188 startingPage "187" @default.
• W2051572188 abstract "Subjects enrolled in studies are not always screened for routine habits such as smoking. Personal history is not always reliable and therefore an objective biomarker is necessary to screen for smokers. The objectives of this article were to review the metabolism of nicotine and other metabolic considerations associated with smoking; to review some of the routine methods used to assess exposure to nicotine-containing products; to revisit cotinine breakpoints utilized to distinguish smokers from non-smokers during screening for clinical trials; to assess the utility of screening questions regarding smoking practices; and to recommend standards for clinical pharmacology studies. The results indicated that cotinine levels serve as a useful biomarker of tobacco exposure; racial issues may be clinically relevant in determining smoking status; cessation of smoking should occur at least 14 days prior to the start of the study; adverse effects from nicotine withdrawal such as craving, hunger and weight gain may persist for more than 6 months; potential metabolic interactions via cytochrome P2A6 and P1A2 need to be considered when designing a study; and the use of a single calibrator as a breakpoint is acceptable if a categorical outcome such as 'smoker' versus 'non-smoker' is desired. Nicotine from food products is not expected to impact assay sensitivity or to be clinically relevant; a serum cotinine concentration of 10 ng ml(-1) be employed as a breakpoint for non-smokers versus smokers; other non-invasive alternatives are collection of urine, saliva, or hair (with suggested breakpoints of 200 ng ml(-1), 5 ng ml(-1) and 0.3 ng mg(-1), respectively; screening questions be accompanied by testing for cotinine; and the inclusion of smokers in studies should be considered once the impact of smoking on the targeted population is understood." @default.
• W2051572188 created "2016-06-24" @default.
• W2051572188 creator A5021144115 @default.
• W2051572188 creator A5088076062 @default.
• W2051572188 date "2003-01-01" @default.
• W2051572188 modified "2023-10-02" @default.
• W2051572188 title "Clinical considerations in study designs that use cotinine as a biomarker" @default.
• W2051572188 cites W1503367288 @default.
• W2051572188 cites W1791887780 @default.
• W2051572188 cites W1880163345 @default.
• W2051572188 cites W1964445032 @default.
• W2051572188 cites W1967991782 @default.
• W2051572188 cites W1973050022 @default.
• W2051572188 cites W1973269259 @default.
• W2051572188 cites W1976260393 @default.
• W2051572188 cites W1976573070 @default.
• W2051572188 cites W1983882432 @default.
• W2051572188 cites W1984409435 @default.
• W2051572188 cites W1988723377 @default.
• W2051572188 cites W1993780682 @default.
• W2051572188 cites W1996646230 @default.
• W2051572188 cites W1999084888 @default.
• W2051572188 cites W2017673885 @default.
• W2051572188 cites W2020625645 @default.
• W2051572188 cites W2021089766 @default.
• W2051572188 cites W2028446527 @default.
• W2051572188 cites W2031596569 @default.
• W2051572188 cites W2032114959 @default.
• W2051572188 cites W2034020971 @default.
• W2051572188 cites W2036539468 @default.
• W2051572188 cites W2042566010 @default.
• W2051572188 cites W2043907269 @default.
• W2051572188 cites W2044318646 @default.
• W2051572188 cites W2044833842 @default.
• W2051572188 cites W2046475541 @default.
• W2051572188 cites W2048190414 @default.
• W2051572188 cites W2049107427 @default.
• W2051572188 cites W2050352549 @default.
• W2051572188 cites W2061088592 @default.
• W2051572188 cites W2066503212 @default.
• W2051572188 cites W2072980021 @default.
• W2051572188 cites W2086047671 @default.
• W2051572188 cites W2110135880 @default.
• W2051572188 cites W2115862458 @default.
• W2051572188 cites W2122502474 @default.
• W2051572188 cites W2142259952 @default.
• W2051572188 cites W2145370692 @default.
• W2051572188 cites W2228339316 @default.
• W2051572188 cites W2328574634 @default.
• W2051572188 cites W2328901850 @default.
• W2051572188 cites W2415082840 @default.
• W2051572188 cites W4232130519 @default.
• W2051572188 doi "https://doi.org/10.1080/13547500310012545" @default.
• W2051572188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12944172" @default.
• W2051572188 hasPublicationYear "2003" @default.
• W2051572188 type Work @default.
• W2051572188 sameAs 2051572188 @default.
• W2051572188 citedByCount "114" @default.
• W2051572188 countsByYear W20515721882012 @default.
• W2051572188 countsByYear W20515721882013 @default.
• W2051572188 countsByYear W20515721882014 @default.
• W2051572188 countsByYear W20515721882015 @default.
• W2051572188 countsByYear W20515721882016 @default.
• W2051572188 countsByYear W20515721882017 @default.
• W2051572188 countsByYear W20515721882018 @default.
• W2051572188 countsByYear W20515721882019 @default.
• W2051572188 countsByYear W20515721882020 @default.
• W2051572188 countsByYear W20515721882021 @default.
• W2051572188 countsByYear W20515721882022 @default.
• W2051572188 countsByYear W20515721882023 @default.
• W2051572188 crossrefType "journal-article" @default.
• W2051572188 hasAuthorship W2051572188A5021144115 @default.
• W2051572188 hasAuthorship W2051572188A5088076062 @default.
• W2051572188 hasConcept C126322002 @default.
• W2051572188 hasConcept C138040679 @default.
• W2051572188 hasConcept C142724271 @default.
• W2051572188 hasConcept C196013638 @default.
• W2051572188 hasConcept C204787440 @default.
• W2051572188 hasConcept C27081682 @default.
• W2051572188 hasConcept C2776087441 @default.
• W2051572188 hasConcept C2776319443 @default.
• W2051572188 hasConcept C2777843972 @default.
• W2051572188 hasConcept C2779547902 @default.
• W2051572188 hasConcept C2780026642 @default.
• W2051572188 hasConcept C2781197716 @default.
• W2051572188 hasConcept C2908647359 @default.
• W2051572188 hasConcept C3019190695 @default.
• W2051572188 hasConcept C42407357 @default.
• W2051572188 hasConcept C526171541 @default.
• W2051572188 hasConcept C535046627 @default.
• W2051572188 hasConcept C55493867 @default.
• W2051572188 hasConcept C62231903 @default.
• W2051572188 hasConcept C71924100 @default.
• W2051572188 hasConcept C86745063 @default.
• W2051572188 hasConcept C86803240 @default.
• W2051572188 hasConcept C99454951 @default.
• W2051572188 hasConceptScore W2051572188C126322002 @default.
• W2051572188 hasConceptScore W2051572188C138040679 @default.

• next