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• W2051604775 startingPage "347" @default.
• W2051604775 abstract "We studied the expression of messenger ribonucleic acids (mRNAs) for neurotrophins and neurotrophin receptors in the rat pituitary gland and examined the influence of adrenal hormones on their mRNA levels, using in situ hybridization and Northern blot analysis. The only neurotrophin present at detectable levels in the pituitary was brain-derived neurotrophic factor (BDNF), which was observed in the anterior and intermediate lobes. Several transcripts of the putative receptor for BDNF, trk B, were present in the anterior and posterior lobes of the pituitary. A low amount of trkC mRNA was found in both the anterior and the intermediate lobe. Dexamethasone treatment decreased both BDNF and trkB mRNA levels in the anterior lobe of the pituitary. Adrenalectomy had no effect on trk B expression, but it decreased BDNF mRNA levels in comparison to the control animals. This effect could not be reversed by dexamethasone substitution, suggesting that BDNF mRNA levels may be regulated not only by glucocorticoids but also by other adrenal hormones. These results demonstrate that BDNF, trkB and trkC are expressed in the pituitary gland and that glucocorticoids and possibly other adrenal hormones may modulate pituitary functions by regulating the expression of neurotrophic factors and their receptors. Whether BDNF acts as a secreted hormone, a trophic factor, or has autocrine/paracrine functions within the pituitary through its receptor, trkB, remains to be studied." @default.
• W2051604775 created "2016-06-24" @default.
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• W2051604775 date "1994-12-01" @default.
• W2051604775 modified "2023-10-18" @default.
• W2051604775 title "Neurotrophins and their receptors in the rat pituitary gland: regulation of BDNF and trk B mRNA levels by adrenal hormones" @default.
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• W2051604775 doi "https://doi.org/10.1016/0169-328x(94)90022-1" @default.
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• W2051604775 hasPublicationYear "1994" @default.
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