FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051610866> ?p ?o ?g. }

• W2051610866 endingPage "437" @default.
• W2051610866 startingPage "431" @default.
• W2051610866 abstract "The objective of the present study was to evaluate anti-inflammatory effects of betulinic acid on lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Pretreatment of betulinic acid significantly attenuated LPSinduced NO production and protein expression of iNOS. Betulinic acid also significantly suppressed LPS-induced release and expression of cytokines such as TNF-α and IL-1β. Furthermore, betulinic acid significantly suppressed LPSinduced MMP-9 expression, which has been suggested to play an important role in the migration of activated microglia. In order to understand the possible mechanism by which betulinic acid suppresses LPS-induced cytokine production and migration of microglia, the role of NF-kB, a major proinflammatory transcription factor, was examined. Betulinic acid significantly suppressed LPS-induced degradation of IkB, which retains NF-kB in the cytoplasm. Therefore, nuclear translocation of NF-kB upon LPS stimulation was significantly suppressed bybetulinic acid. Taken together, the present study for the first time demonstrates thatbetulinic acid possesses anti-inflammatory activity and inhibition of microglial migration through the suppression of nuclear translocation of NF-kB in BV2 microglial cells." @default.
• W2051610866 created "2016-06-24" @default.
• W2051610866 creator A5014613700 @default.
• W2051610866 date "2011-10-30" @default.
• W2051610866 modified "2023-09-24" @default.
• W2051610866 title "Betulinic Acid Inhibits LPS-Induced MMP-9 Expression by Suppressing NF-kB Activation in BV2 Microglial Cells" @default.
• W2051610866 cites W1817103017 @default.
• W2051610866 cites W1824808675 @default.
• W2051610866 cites W1990461254 @default.
• W2051610866 cites W1992598058 @default.
• W2051610866 cites W2004318097 @default.
• W2051610866 cites W2005268885 @default.
• W2051610866 cites W2015002417 @default.
• W2051610866 cites W2026985565 @default.
• W2051610866 cites W2027584590 @default.
• W2051610866 cites W2030174218 @default.
• W2051610866 cites W2030697317 @default.
• W2051610866 cites W2031246461 @default.
• W2051610866 cites W2033966441 @default.
• W2051610866 cites W2035272016 @default.
• W2051610866 cites W2052798492 @default.
• W2051610866 cites W2056351034 @default.
• W2051610866 cites W2058837791 @default.
• W2051610866 cites W2061747759 @default.
• W2051610866 cites W2063490157 @default.
• W2051610866 cites W2074150439 @default.
• W2051610866 cites W2077409457 @default.
• W2051610866 cites W2079241115 @default.
• W2051610866 cites W2079411600 @default.
• W2051610866 cites W2082831171 @default.
• W2051610866 cites W2091899079 @default.
• W2051610866 cites W2101129399 @default.
• W2051610866 cites W2102732416 @default.
• W2051610866 cites W2106877484 @default.
• W2051610866 cites W2108686626 @default.
• W2051610866 cites W2109759840 @default.
• W2051610866 cites W2115090099 @default.
• W2051610866 cites W2117909041 @default.
• W2051610866 cites W2128753121 @default.
• W2051610866 cites W2148642633 @default.
• W2051610866 cites W2155093913 @default.
• W2051610866 cites W2169749991 @default.
• W2051610866 cites W2335925695 @default.
• W2051610866 doi "https://doi.org/10.4062/biomolther.2011.19.4.431" @default.
• W2051610866 hasPublicationYear "2011" @default.
• W2051610866 type Work @default.
• W2051610866 sameAs 2051610866 @default.
• W2051610866 citedByCount "8" @default.
• W2051610866 countsByYear W20516108662012 @default.
• W2051610866 countsByYear W20516108662013 @default.
• W2051610866 countsByYear W20516108662015 @default.
• W2051610866 countsByYear W20516108662018 @default.
• W2051610866 countsByYear W20516108662020 @default.
• W2051610866 countsByYear W20516108662021 @default.
• W2051610866 countsByYear W20516108662022 @default.
• W2051610866 crossrefType "journal-article" @default.
• W2051610866 hasAuthorship W2051610866A5014613700 @default.
• W2051610866 hasBestOaLocation W20516108661 @default.
• W2051610866 hasConcept C109523444 @default.
• W2051610866 hasConcept C185592680 @default.
• W2051610866 hasConcept C203014093 @default.
• W2051610866 hasConcept C2776914184 @default.
• W2051610866 hasConcept C2777730290 @default.
• W2051610866 hasConcept C2777829905 @default.
• W2051610866 hasConcept C2779830541 @default.
• W2051610866 hasConcept C54355233 @default.
• W2051610866 hasConcept C55493867 @default.
• W2051610866 hasConcept C86803240 @default.
• W2051610866 hasConcept C87753298 @default.
• W2051610866 hasConcept C95444343 @default.
• W2051610866 hasConcept C98274493 @default.
• W2051610866 hasConceptScore W2051610866C109523444 @default.
• W2051610866 hasConceptScore W2051610866C185592680 @default.
• W2051610866 hasConceptScore W2051610866C203014093 @default.
• W2051610866 hasConceptScore W2051610866C2776914184 @default.
• W2051610866 hasConceptScore W2051610866C2777730290 @default.
• W2051610866 hasConceptScore W2051610866C2777829905 @default.
• W2051610866 hasConceptScore W2051610866C2779830541 @default.
• W2051610866 hasConceptScore W2051610866C54355233 @default.
• W2051610866 hasConceptScore W2051610866C55493867 @default.
• W2051610866 hasConceptScore W2051610866C86803240 @default.
• W2051610866 hasConceptScore W2051610866C87753298 @default.
• W2051610866 hasConceptScore W2051610866C95444343 @default.
• W2051610866 hasConceptScore W2051610866C98274493 @default.
• W2051610866 hasIssue "4" @default.
• W2051610866 hasLocation W20516108661 @default.
• W2051610866 hasOpenAccess W2051610866 @default.
• W2051610866 hasPrimaryLocation W20516108661 @default.
• W2051610866 hasRelatedWork W1484701625 @default.
• W2051610866 hasRelatedWork W1990461254 @default.
• W2051610866 hasRelatedWork W2040423913 @default.
• W2051610866 hasRelatedWork W2051610866 @default.
• W2051610866 hasRelatedWork W2743513023 @default.
• W2051610866 hasRelatedWork W2889514518 @default.
• W2051610866 hasRelatedWork W2946580071 @default.
• W2051610866 hasRelatedWork W3006433254 @default.
• W2051610866 hasRelatedWork W4281290245 @default.
• W2051610866 hasRelatedWork W4321609898 @default.

• next