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- W2051615156 abstract "Lectin-like oxidized LDL receptor-1 (LOX-1) is a unique scavenger receptor that mediates the binding and uptake of oxidized LDL (ox-LDL) by vascular cells during the development of atherosclerosis. Exposure to ox-LDL induces LOX-1 expression and LOX-1-dependent biological activities, such as activation of NF-κB, a nuclear factor important for signal transduction in inflammation. Accumulating evidence indicates that male hormones may regulate expression of LOX-1 and NF-κB as well as atherogenesis. Deficiency or low levels of the male hormone testosterone promote LOX-1 expression and NF-κB activation, while testosterone replacement therapy reduces the expression of LOX-1 and the activation of NF-κB, thereby protecting the arterial wall against atherogenesis." @default.
- W2051615156 created "2016-06-24" @default.
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- W2051615156 creator A5018801839 @default.
- W2051615156 date "2013-11-01" @default.
- W2051615156 modified "2023-10-17" @default.
- W2051615156 title "LOX-1: A male hormone-regulated scavenger receptor for atherosclerosis" @default.
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- W2051615156 doi "https://doi.org/10.1016/j.vph.2013.10.003" @default.
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