FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051626595> ?p ?o ?g. }

• W2051626595 endingPage "392" @default.
• W2051626595 startingPage "385" @default.
• W2051626595 abstract "Renal cell carcinoma (RCC) biomarkers are necessary for diagnosis and prognosis. They serve to monitor therapy response and follow-up, as drug targets, and therapy predictors in personalized treatments. Proteomics is a suitable method for biomarker discovery. Here we investigate differential protein expression in RCC, and we evaluate Reticulocalbin 1 (RCN1) use as a new potential marker. Neoplastic and healthy tissue samples were collected from 24 RCC patients during radical nephrectomy. Seven specimens were firstly processed by proteomic analysis (2-DE and MALDI-TOF) and 18 differentially expressed proteins from neoplastic and healthy renal tissues were identified. Among them, RCN1 was over-expressed in all cancer specimens analyzed by proteomics. Consequently RCN1 use as a potential marker was further evaluated in all 24 donors. RCN1 expression was verified by Western blotting (WB) and immunohistochemistry (IHC). WB analysis confirmed RCN1 over-expression in 21 out of 24 tumor specimens, whereas IHC displayed focal or diffuse expression of RCN1 in all 24 RCC tissues. Thus RCN1 appears as a potential marker for clinical approaches. A larger histopathological trial will clarify the prognostic value of RCN1 in RCC. The present work aimed at finding new biomarkers for RCC – a life-threatening disease characterized by high incidence in Western countries – by performing differential proteomic analysis of neoplastic and normal renal tissues obtained from a small cohort of RCC patients. Some of the identified proteins have been previously associated to renal cancer however data confirming the possible use of these proteins in clinical practice are not available to date. By IHC we demonstrated that RCN1 could be easily employed in clinical practice, confirming RCN1 over-expression in RCC tissues of all examined patients, and weak protein expression in healthy renal tissues only in correspondence to the renal tubule section. These data indicate a promising role of RCN1 as a possible marker in RCC and indicate the proximal convoluted renal tubule as a putative origin point for RCC. Since IHC staining displayed different grades of intensity in tested tissues, we hypothesized that RCN1 could also be employed as a prognostic marker or as a response predictor for RCC-targeted therapy. To test such a hypothesis, a larger retrospective trial on paraffin-embedded tissues obtained from radical or partial nephrectomy of RCC patients is planned to be performed by our group." @default.
• W2051626595 created "2016-06-24" @default.
• W2051626595 creator A5009083499 @default.
• W2051626595 creator A5017533750 @default.
• W2051626595 creator A5019912243 @default.
• W2051626595 creator A5025628952 @default.
• W2051626595 creator A5036980995 @default.
• W2051626595 creator A5037876895 @default.
• W2051626595 creator A5057334164 @default.
• W2051626595 creator A5057912282 @default.
• W2051626595 creator A5062868264 @default.
• W2051626595 creator A5064787650 @default.
• W2051626595 creator A5067670127 @default.
• W2051626595 creator A5070466453 @default.
• W2051626595 creator A5085160183 @default.
• W2051626595 creator A5085447576 @default.
• W2051626595 creator A5089111895 @default.
• W2051626595 creator A5089164502 @default.
• W2051626595 creator A5091443682 @default.
• W2051626595 date "2013-10-01" @default.
• W2051626595 modified "2023-10-03" @default.
• W2051626595 title "Proteomic identification of Reticulocalbin 1 as potential tumor marker in renal cell carcinoma" @default.
• W2051626595 cites W1505418463 @default.
• W2051626595 cites W1548453476 @default.
• W2051626595 cites W1970340071 @default.
• W2051626595 cites W1975124017 @default.
• W2051626595 cites W1975507000 @default.
• W2051626595 cites W1976043651 @default.
• W2051626595 cites W1977998325 @default.
• W2051626595 cites W1979090867 @default.
• W2051626595 cites W1981010222 @default.
• W2051626595 cites W1985630413 @default.
• W2051626595 cites W1989284989 @default.
• W2051626595 cites W1990940222 @default.
• W2051626595 cites W1995383273 @default.
• W2051626595 cites W1995847887 @default.
• W2051626595 cites W2003925684 @default.
• W2051626595 cites W2012932145 @default.
• W2051626595 cites W2015266394 @default.
• W2051626595 cites W2020224936 @default.
• W2051626595 cites W2044572647 @default.
• W2051626595 cites W2060290469 @default.
• W2051626595 cites W2066562933 @default.
• W2051626595 cites W2089760187 @default.
• W2051626595 cites W2097179367 @default.
• W2051626595 cites W2100837269 @default.
• W2051626595 cites W2111782645 @default.
• W2051626595 cites W2129217857 @default.
• W2051626595 cites W2136704317 @default.
• W2051626595 cites W2141145854 @default.
• W2051626595 cites W2165190057 @default.
• W2051626595 doi "https://doi.org/10.1016/j.jprot.2013.07.018" @default.
• W2051626595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23916412" @default.
• W2051626595 hasPublicationYear "2013" @default.
• W2051626595 type Work @default.
• W2051626595 sameAs 2051626595 @default.
• W2051626595 citedByCount "33" @default.
• W2051626595 countsByYear W20516265952014 @default.
• W2051626595 countsByYear W20516265952015 @default.
• W2051626595 countsByYear W20516265952016 @default.
• W2051626595 countsByYear W20516265952017 @default.
• W2051626595 countsByYear W20516265952018 @default.
• W2051626595 countsByYear W20516265952019 @default.
• W2051626595 countsByYear W20516265952020 @default.
• W2051626595 countsByYear W20516265952021 @default.
• W2051626595 countsByYear W20516265952022 @default.
• W2051626595 countsByYear W20516265952023 @default.
• W2051626595 crossrefType "journal-article" @default.
• W2051626595 hasAuthorship W2051626595A5009083499 @default.
• W2051626595 hasAuthorship W2051626595A5017533750 @default.
• W2051626595 hasAuthorship W2051626595A5019912243 @default.
• W2051626595 hasAuthorship W2051626595A5025628952 @default.
• W2051626595 hasAuthorship W2051626595A5036980995 @default.
• W2051626595 hasAuthorship W2051626595A5037876895 @default.
• W2051626595 hasAuthorship W2051626595A5057334164 @default.
• W2051626595 hasAuthorship W2051626595A5057912282 @default.
• W2051626595 hasAuthorship W2051626595A5062868264 @default.
• W2051626595 hasAuthorship W2051626595A5064787650 @default.
• W2051626595 hasAuthorship W2051626595A5067670127 @default.
• W2051626595 hasAuthorship W2051626595A5070466453 @default.
• W2051626595 hasAuthorship W2051626595A5085160183 @default.
• W2051626595 hasAuthorship W2051626595A5085447576 @default.
• W2051626595 hasAuthorship W2051626595A5089111895 @default.
• W2051626595 hasAuthorship W2051626595A5089164502 @default.
• W2051626595 hasAuthorship W2051626595A5091443682 @default.
• W2051626595 hasBestOaLocation W20516265952 @default.
• W2051626595 hasConcept C104317684 @default.
• W2051626595 hasConcept C121608353 @default.
• W2051626595 hasConcept C126322002 @default.
• W2051626595 hasConcept C142724271 @default.
• W2051626595 hasConcept C143998085 @default.
• W2051626595 hasConcept C193270364 @default.
• W2051626595 hasConcept C204232928 @default.
• W2051626595 hasConcept C2777472916 @default.
• W2051626595 hasConcept C2780091579 @default.
• W2051626595 hasConcept C2780227381 @default.
• W2051626595 hasConcept C2781197716 @default.
• W2051626595 hasConcept C2781447364 @default.

• next