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- W2051643721 abstract "Introduction: Strict lifelong compliance to a gluten-free diet minimizes the risk for long-term complications. The present study was designed to compare iron status in patients with celiac disease who comply with a gluten-free diet with those with dietary transgression. Methods: One hundred and seven patients with celiac disease diagnosed according to the ESPGHAN recommendations, in at least one year of dietary treatment, were studied. The median age of patients was 11.5 years. We also studied 244 first degree relatives without celiac disease, who were negative to human tissular antitransglutaminase antibody with non-IgA imunoglobulin deficiency. All patients and relatives were analyzed for human tissular antitransglutaminase antibody (Kit tTG - The Binding Site), IgA imunoglobulin, hemoglobin (anemia: according to WHO’s definition) and serum ferritin (iron deficiency: serum ferritin <12 ng/mL). Compliance with the gluten-free diet was defined when negative human tissular antitransglutaminase antibody (<4 U/mL) with non-IgA imunoglobulin deficiency; whereas, dietary transgression when positive human tissular antitransglutaminase antibody (>= 4 U/mL). Results: Dietary compliance was observed in 60 (56.1%) patients, while dietary transgression in 47 (43.9%) patients. Nine patients and 28 relatives were excluded because they had low hemoglobin with normal serum ferritin. The proportion of patients with iron deficiency anemia or iron deficiency was higher (26/47; 55.3%) in those with dietary transgression than in those with dietary compliance (8/51; 15.7%; p<0.001) - odds ratio= 6.7 (95% coefficient interval: 2.4 – 19.3). The proportion of relatives with iron deficiency anemia or iron deficiency was 6.9% (15/216) lower than patients with dietary transgression (p<0.001). Conclusion: Dietary transgression, observed in 43.9% of patients, was a risk factor of iron deficiency in patients with celiac disease." @default.
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- W2051643721 date "2004-06-01" @default.
- W2051643721 modified "2023-09-30" @default.
- W2051643721 title "P0404 DIETARY TRANSGRESSION IN PATIENTS WITH CELIAC DISEASE AS A RISK FACTOR OF IRON DEFICIENCY" @default.
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- W2051643721 doi "https://doi.org/10.1097/00005176-200406001-00528" @default.
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