FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051652691> ?p ?o ?g. }

• W2051652691 endingPage "1215" @default.
• W2051652691 startingPage "1209" @default.
• W2051652691 abstract "Current nutrient requirement models assume fixed efficiencies of absorbed amino acid (AA) conversion to milk protein. Regulation of mammary protein synthesis (PS) potentially violates this assumption by changing the relationship between AA supply and milk protein output. The objective of this study was to investigate the effects of essential AA (EAA) and insulin on cellular signaling and PS rates in bovine mammary cells. MAC-T cells were subjected to 0 or 100% of normal EAA concentrations in DMEM/F12 and 0 or 100 μg insulin/L in a 2 × 2 factorial arrangement of treatments. Lactogenic bovine mammary tissue slices (MTS) were subjected to the same treatments, except low-EAA was 5% of normal DMEM/F12 concentrations. In MAC-T cells, EAA increased phosphorylation of mammalian target of rapamycin (mTOR; Ser2448), ribosomal protein S6 kinase 1 (S6K1; Thr389), eIF4E binding protein 1 (4EBP1; Thr37/46), and insulin receptor substrate 1 (IRS1; Ser1101), and reduced phosphorylation of eukaryotic elongation factor 2 (eEF2; Thr56) and eukaryotic initiation factor (eIF) 2-α (Ser51). In the presence of insulin, phosphorylation of Akt (Ser473), mTOR, S6K1, 4EBP1, and IRS1 increased in MAC-T cells. In MTS, EAA had similar effects on phosphorylation of signaling proteins and increased mammary PS rates. Insulin did not affect MTS signaling, perhaps due to inadequate levels. Effects of EAA and insulin were independent and additive for mTOR signaling in MAC-T cells. EAA did not inhibit insulin stimulation of Akt phosphorylation. PS rates were strongly associated with phosphorylation of 4EBP1 and eEF2 in MTS. EAA availability affected translation initiation and elongation control points to more strongly regulate PS than insulin." @default.
• W2051652691 created "2016-06-24" @default.
• W2051652691 creator A5003954493 @default.
• W2051652691 creator A5022094888 @default.
• W2051652691 creator A5069459569 @default.
• W2051652691 creator A5072709566 @default.
• W2051652691 creator A5089792210 @default.
• W2051652691 date "2011-06-01" @default.
• W2051652691 modified "2023-10-18" @default.
• W2051652691 title "Essential Amino Acids Regulate Both Initiation and Elongation of mRNA Translation Independent of Insulin in MAC-T Cells and Bovine Mammary Tissue Slices" @default.
• W2051652691 cites W141764926 @default.
• W2051652691 cites W172856881 @default.
• W2051652691 cites W1931189258 @default.
• W2051652691 cites W1964188972 @default.
• W2051652691 cites W1964321721 @default.
• W2051652691 cites W1974156415 @default.
• W2051652691 cites W1986846519 @default.
• W2051652691 cites W2001259221 @default.
• W2051652691 cites W2004128695 @default.
• W2051652691 cites W2008410413 @default.
• W2051652691 cites W2009322120 @default.
• W2051652691 cites W2012130540 @default.
• W2051652691 cites W2016698855 @default.
• W2051652691 cites W2028740703 @default.
• W2051652691 cites W2034783371 @default.
• W2051652691 cites W2039706703 @default.
• W2051652691 cites W2041234977 @default.
• W2051652691 cites W2047785908 @default.
• W2051652691 cites W2056982205 @default.
• W2051652691 cites W2065151741 @default.
• W2051652691 cites W2069052337 @default.
• W2051652691 cites W2078281362 @default.
• W2051652691 cites W2079537922 @default.
• W2051652691 cites W2081221632 @default.
• W2051652691 cites W2085663116 @default.
• W2051652691 cites W2094853437 @default.
• W2051652691 cites W2098869037 @default.
• W2051652691 cites W2104411771 @default.
• W2051652691 cites W2105663186 @default.
• W2051652691 cites W2109684453 @default.
• W2051652691 cites W2119651799 @default.
• W2051652691 cites W2121074067 @default.
• W2051652691 cites W2123996523 @default.
• W2051652691 cites W2126334171 @default.
• W2051652691 cites W2131010552 @default.
• W2051652691 cites W2136954505 @default.
• W2051652691 cites W2152135348 @default.
• W2051652691 cites W2153497031 @default.
• W2051652691 cites W2154299658 @default.
• W2051652691 cites W2165689729 @default.
• W2051652691 cites W2168046351 @default.
• W2051652691 cites W2169685103 @default.
• W2051652691 cites W2169980814 @default.
• W2051652691 cites W2411605924 @default.
• W2051652691 cites W2414934949 @default.
• W2051652691 cites W4256602755 @default.
• W2051652691 doi "https://doi.org/10.3945/jn.110.136143" @default.
• W2051652691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21525255" @default.
• W2051652691 hasPublicationYear "2011" @default.
• W2051652691 type Work @default.
• W2051652691 sameAs 2051652691 @default.
• W2051652691 citedByCount "80" @default.
• W2051652691 countsByYear W20516526912012 @default.
• W2051652691 countsByYear W20516526912013 @default.
• W2051652691 countsByYear W20516526912014 @default.
• W2051652691 countsByYear W20516526912015 @default.
• W2051652691 countsByYear W20516526912016 @default.
• W2051652691 countsByYear W20516526912017 @default.
• W2051652691 countsByYear W20516526912018 @default.
• W2051652691 countsByYear W20516526912019 @default.
• W2051652691 countsByYear W20516526912020 @default.
• W2051652691 countsByYear W20516526912021 @default.
• W2051652691 countsByYear W20516526912022 @default.
• W2051652691 countsByYear W20516526912023 @default.
• W2051652691 crossrefType "journal-article" @default.
• W2051652691 hasAuthorship W2051652691A5003954493 @default.
• W2051652691 hasAuthorship W2051652691A5022094888 @default.
• W2051652691 hasAuthorship W2051652691A5069459569 @default.
• W2051652691 hasAuthorship W2051652691A5072709566 @default.
• W2051652691 hasAuthorship W2051652691A5089792210 @default.
• W2051652691 hasBestOaLocation W20516526911 @default.
• W2051652691 hasConcept C104202773 @default.
• W2051652691 hasConcept C112446052 @default.
• W2051652691 hasConcept C11960822 @default.
• W2051652691 hasConcept C126322002 @default.
• W2051652691 hasConcept C134018914 @default.
• W2051652691 hasConcept C185592680 @default.
• W2051652691 hasConcept C201624660 @default.
• W2051652691 hasConcept C2777391703 @default.
• W2051652691 hasConcept C2779306644 @default.
• W2051652691 hasConcept C2780926556 @default.
• W2051652691 hasConcept C55493867 @default.
• W2051652691 hasConcept C62478195 @default.
• W2051652691 hasConcept C71924100 @default.
• W2051652691 hasConcept C75217442 @default.
• W2051652691 hasConcept C86554907 @default.
• W2051652691 hasConcept C86803240 @default.
• W2051652691 hasConceptScore W2051652691C104202773 @default.

• next