FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051653669> ?p ?o ?g. }

• W2051653669 endingPage "241" @default.
• W2051653669 startingPage "233" @default.
• W2051653669 abstract "For the analysis of degraded DNA in disaster victim identification (DVI) and criminal investigations, single nucleotide polymorphisms (SNPs) have been recognized as promising markers mainly because they can be analyzed in short sized amplicons. Most SNPs are bi-allelic and are thereby ineffective to detect mixtures, which may lead to incorrect genotyping. We developed an algorithm to find non-binary (i.e. tri-allelic or tetra-allelic) SNPs in the NCBI dbSNP database. We selected 31 potential tri-allelic SNPs with a minor allele frequency of at least 10%. The tri-allelic nature was confirmed for 15 SNPs residing on 14 different chromosomes. Multiplex SNaPshot™ assays were developed, and the allele frequencies of 16 SNPs were determined among 153 Dutch and 111 Netherlands Antilles reference samples. Using these multiplex SNP assays, the presence of a mixture of two DNA samples in a ratio up to 1:8 could be recognized reliably. Furthermore, we compared the genotyping efficiency of the tri-allelic SNP markers and short tandem repeat (STR) markers by analyzing artificially degraded DNA and DNA from 30 approximately 500-year-old bone and molar samples. In both types of degraded DNA samples, the larger sized STR amplicons failed to amplify whereas the tri-allelic SNP markers still provided valuable information. In conclusion, tri-allelic SNP markers are suited for the analysis of degraded DNA and enable the detection of a second DNA source in a sample." @default.
• W2051653669 created "2016-06-24" @default.
• W2051653669 creator A5001355447 @default.
• W2051653669 creator A5009255152 @default.
• W2051653669 creator A5022162414 @default.
• W2051653669 creator A5046084094 @default.
• W2051653669 creator A5052054322 @default.
• W2051653669 creator A5053215549 @default.
• W2051653669 creator A5067728320 @default.
• W2051653669 creator A5084128801 @default.
• W2051653669 date "2009-09-01" @default.
• W2051653669 modified "2023-10-01" @default.
• W2051653669 title "Tri-allelic SNP markers enable analysis of mixed and degraded DNA samples" @default.
• W2051653669 cites W1516646446 @default.
• W2051653669 cites W1539655807 @default.
• W2051653669 cites W1934928971 @default.
• W2051653669 cites W1976682100 @default.
• W2051653669 cites W2002883926 @default.
• W2051653669 cites W2009814695 @default.
• W2051653669 cites W2013827642 @default.
• W2051653669 cites W2023178384 @default.
• W2051653669 cites W2025659190 @default.
• W2051653669 cites W2037471641 @default.
• W2051653669 cites W2047417387 @default.
• W2051653669 cites W2053232824 @default.
• W2051653669 cites W2062868753 @default.
• W2051653669 cites W2082914843 @default.
• W2051653669 cites W2089646842 @default.
• W2051653669 cites W2096072966 @default.
• W2051653669 cites W2098767365 @default.
• W2051653669 cites W2101294025 @default.
• W2051653669 cites W2104251348 @default.
• W2051653669 cites W2106359530 @default.
• W2051653669 cites W2107134517 @default.
• W2051653669 cites W2111517251 @default.
• W2051653669 cites W2119058058 @default.
• W2051653669 cites W2120726124 @default.
• W2051653669 cites W2131120104 @default.
• W2051653669 cites W2131237610 @default.
• W2051653669 cites W2132497218 @default.
• W2051653669 cites W2137167287 @default.
• W2051653669 cites W2158987476 @default.
• W2051653669 cites W2170059665 @default.
• W2051653669 cites W2283649896 @default.
• W2051653669 doi "https://doi.org/10.1016/j.fsigen.2009.02.003" @default.
• W2051653669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19647708" @default.
• W2051653669 hasPublicationYear "2009" @default.
• W2051653669 type Work @default.
• W2051653669 sameAs 2051653669 @default.
• W2051653669 citedByCount "68" @default.
• W2051653669 countsByYear W20516536692012 @default.
• W2051653669 countsByYear W20516536692013 @default.
• W2051653669 countsByYear W20516536692014 @default.
• W2051653669 countsByYear W20516536692015 @default.
• W2051653669 countsByYear W20516536692016 @default.
• W2051653669 countsByYear W20516536692017 @default.
• W2051653669 countsByYear W20516536692018 @default.
• W2051653669 countsByYear W20516536692019 @default.
• W2051653669 countsByYear W20516536692020 @default.
• W2051653669 countsByYear W20516536692021 @default.
• W2051653669 countsByYear W20516536692022 @default.
• W2051653669 countsByYear W20516536692023 @default.
• W2051653669 crossrefType "journal-article" @default.
• W2051653669 hasAuthorship W2051653669A5001355447 @default.
• W2051653669 hasAuthorship W2051653669A5009255152 @default.
• W2051653669 hasAuthorship W2051653669A5022162414 @default.
• W2051653669 hasAuthorship W2051653669A5046084094 @default.
• W2051653669 hasAuthorship W2051653669A5052054322 @default.
• W2051653669 hasAuthorship W2051653669A5053215549 @default.
• W2051653669 hasAuthorship W2051653669A5067728320 @default.
• W2051653669 hasAuthorship W2051653669A5084128801 @default.
• W2051653669 hasConcept C104317684 @default.
• W2051653669 hasConcept C135763542 @default.
• W2051653669 hasConcept C139275648 @default.
• W2051653669 hasConcept C153209595 @default.
• W2051653669 hasConcept C15546506 @default.
• W2051653669 hasConcept C163691529 @default.
• W2051653669 hasConcept C180754005 @default.
• W2051653669 hasConcept C2781188995 @default.
• W2051653669 hasConcept C31467283 @default.
• W2051653669 hasConcept C35794970 @default.
• W2051653669 hasConcept C49105822 @default.
• W2051653669 hasConcept C54355233 @default.
• W2051653669 hasConcept C54868293 @default.
• W2051653669 hasConcept C59701697 @default.
• W2051653669 hasConcept C61320498 @default.
• W2051653669 hasConcept C8185291 @default.
• W2051653669 hasConcept C86803240 @default.
• W2051653669 hasConcept C90583042 @default.
• W2051653669 hasConceptScore W2051653669C104317684 @default.
• W2051653669 hasConceptScore W2051653669C135763542 @default.
• W2051653669 hasConceptScore W2051653669C139275648 @default.
• W2051653669 hasConceptScore W2051653669C153209595 @default.
• W2051653669 hasConceptScore W2051653669C15546506 @default.
• W2051653669 hasConceptScore W2051653669C163691529 @default.
• W2051653669 hasConceptScore W2051653669C180754005 @default.
• W2051653669 hasConceptScore W2051653669C2781188995 @default.
• W2051653669 hasConceptScore W2051653669C31467283 @default.

• next